Results 51 to 60 of about 22,151 (252)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Guest editorial—the ballyhoo over polar bears
, 2009 Critics have said that there’s little or no justification for the focus that polar bears (Ursus maritimus) have received as a threatened species. Recent studies project dramatic reductions in polar bear numbers in just a few decades, in concert with the ...
Vongraven, Dag
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Polar bear attack on a juvenile narwhal
Fauna Norvegica, 1990 A juvenile female narwhal Monodon monoceros landed at Pond Inlet had several sets of scratches on the posterior part of the body. They were probably made by a polar bear Ursus maritimus in the course of an unsuccessful attack.
Michael C.S. Kingsley
doaj +1 more source
Polar Bear Harvest Patterns Across the Circumpolar Arctic
Frontiers in Conservation Science, 2022 Wildlife harvest remains a conservation concern for many species and assessing patterns of harvest can provide insights on sustainability and inform management. Polar bears (Ursus maritimus) are harvested over a large part of their range by local people.
Dag Vongraven +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Polar bears killed in Svalbard 1987–1992
, 1993 A total of 26 polar bears have been killed in Svalbard since January 1987. Fifteen of these cases were self defense, four precautionary measures, six acts of mercy and one unknown.
Gjertz, Ian +2 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Polar bear visits to human infrastructure increase with sea ice loss, not poor body condition
Arctic ScienceClimate warming has reduced Arctic sea ice, forcing some populations of polar bears (Ursus maritimus Phipps, 1774) to spend more time on land and increasing the potential for encounters with humans.
Danielle Rivet +6 more
doaj +1 more source