Results 61 to 70 of about 591,166 (254)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Polar bear visits to human infrastructure increase with sea ice loss, not poor body condition

Arctic Science
Climate warming has reduced Arctic sea ice, forcing some populations of polar bears (Ursus maritimus Phipps, 1774) to spend more time on land and increasing the potential for encounters with humans.
Danielle Rivet, Ryan Brook, Alex Crawford, Corey Kramer, Michel P. Laforge, Julienne Stroeve, Douglas A. Clark   +6 more
doaj   +1 more source

Polar bear predation on barrier island bird colonies in Arctic Alaska increases with sea-ice decline

Anthropogenic carbon emissions are warming the Arctic, disrupting ecosystems, and changing the behaviour and interactions of their component species. As summer sea ice diminishes, polar bears (Ursus maritimus) are losing access to traditional seal prey ...
Van der Laan, Anneke, Shively, Kayla, Robards, Martin, Divoky, George   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Identifying indicators of polar bear population status

Ecological Indicators
Monitoring trends in large mammal populations is a fundamental component of wildlife management and conservation. However, direct estimates of population size and vital rates of large mammals can be logistically challenging and expensive. Indicators that
Karyn D. Rode, Ryan R. Wilson, Justin A. Crawford, Lori T. Quakenbush   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

An Evolutionarily Young Polar Bear (Ursus maritimus) Endogenous Retrovirus Identified from Next Generation Sequence Data

Viruses, 2015
Transcriptome analysis of polar bear (Ursus maritimus) tissues identified sequences with similarity to Porcine Endogenous Retroviruses (PERV). Based on these sequences, four proviral copies and 15 solo long terminal repeats (LTRs) of a newly described ...
Kyriakos Tsangaras, Jens Mayer, David E. Alquezar-Planas, Alex D. Greenwood   +3 more
doaj   +1 more source

Polar bear foraging in western Hudson Bay. [PDF]

, 2017
28 pages : illustrations (chiefly color), map ; 26 cm.During much of the year, polar bears in western Hudson Bay use energy-conserving hunting tactics, such as still-hunting and stalking, to capture seals from sea-ice platforms. Such hunting allows these
Ellis-Felege, Susan N., Gormezano, Linda J., Barnas, Andrew, 1991-, Rockwell, Robert F., Iles, David T.   +4 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source