Results 71 to 80 of about 2,094,495 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

open access: yesFrontiers in Chemistry
Traditional Chinese medicine (TCM), with a history spanning over 2,000 years, contains numerous strongly polar components that are increasingly the focus of pharmaceutical and analytical research.
Yuanyuan Wu   +10 more
doaj   +1 more source

Review of LASHIPA: History of Large Scale Resource Exploitation in Polar Areas, edited by Louwrens Hacquebord

open access: yes, 2013
This collection of papers reflects the results of two separate but related research projects: the International Polar Year (IPY) project History of Large Scale Resource Exploitation in Polar Areas (LASHIPA) and a European Science Foundation Collaborative
Capelotti, P. J.
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Deterioration of partially hydrogenated soybean oil used in deep fat frying of a meat food

open access: yesGrasas y Aceites, 2005
The deterioration of partially hydrogenated soybean oil used in deep fat frying of a meat food called milanesa for evaluating its behavior according to the Argentinian Food Codex (CAA) at laboratory scale was studied.
María Daniela Juárez   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Analysis of used frying fats for biodiesel production

open access: yesGrasas y Aceites, 2008
Used frying fats and oils with highly variable and uncontrolled quality are used for the production of biodiesel . The objective of this study was to define the analytical methods useful to obtaining information on the quality of the used frying oils as ...
M. V. Ruiz-Méndez   +3 more
doaj   +1 more source

Review of 100 facts: polar lands; 365 penguins; Amazing Arctic & Antarctic projects you can build yourself; Apun: the Arctic snow; Matthew Henson: the quest for the North Pole; Polar bears in danger; Polar regions; Race to the South Poleetc.

open access: yes, 2010
The polar regions have captured the world’s attention, and children’s book authors and publishers are no exception. These dozen titles are just a sample of the bucketload of polar-themed children’s books that have been published during the last couple of
Goldman, Helle
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Influence of the Mozzarella Type on Chemical and Sensory Properties of “Pizza Margherita”

open access: yesFoods
Background: According to Neapolitan Pizza Traditional Specialty Guaranteed (TSG) regulation, Mozzarella di Bufala Campana and Fiordilatte mozzarella are the exclusive cheeses to be used, together with tomato and extra virgin olive oil (EVOO), to season ...
Amalia Piscopo   +6 more
doaj   +1 more source

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