Results 51 to 60 of about 76,104 (300)

Polar coordinates

open access: yes, 2011
Points in two-dimensional space are commonly specified using either rectilinear (x- and y-) coordinates or polar (radial and angular) coordinates. Use the locator to see how these coordinates change as a point moves in the planeComponente Curricular ...
Boucher, Chris
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

A new initialization technique in polar coordinates for Particle Swarm Optimization and Polar PSO [PDF]

open access: yes, 2017
Particle Swarm Optimization (PSO) is one of the famous algorithms inspired by the natural behavior of a swarm (particles). However, it is used to solve n-dimensional problems in search space. One of its modified versions a Polar Particle Swarm Optimizer,
Nasrudin, Mohammad Faidzul; Center for Artificial Intelligence Technology (CAIT), Faculty of Information Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A low complexity pilot assignment algorithm based on user polar coordinates in CF-mMIMO systems

open access: yesDianxin kexue, 2023
Absrtact: In order to reduce the pilot contamination in the cell-free massive multi-input multi-output (MIMO) system, a low complexity pilot assignment algorithm based on user polar coordinates was proposed.Firstly, a Gaussian weighted density algorithm ...
Shao GUO, Peng PAN, Yaozong FAN
doaj   +2 more sources

Multiproduct Uniform Polar Quantizer [PDF]

open access: yesRadioengineering, 2015
The aim of this paper is to reduce the complexity of the unrestricted uniform polar quantizer (UUPQ), keeping its high performances. To achieve this, in this paper we propose the multiproduct uniform polar quantizer (MUPQ), where several consecutive ...
M. R. Dincic, Z. H. Peric
doaj  

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