Results 91 to 100 of about 79,547 (300)

Bernstein-Type Inequalities for the Polar Derivative of a Polynomial [PDF]

open access: yes, 2012
Inequalities of Markov and Bernstein were the starting point of considerable literature in polynomial approximation theory. The problem of obtaining exact new bonds, the improvements and the extensions of some old results for the maximum modulus of P'(z)
Rather, Nisar Ahmad (Guide)   +1 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A Molecular Electron Density Theory Study of the Chemoselectivity, Regioselectivity, and Diastereofacial Selectivity in the Synthesis of an Anticancer Spiroisoxazoline derived from α-Santonin

open access: yesMolecules, 2019
The [3 + 2] cycloaddition (32CA) reaction of an α-santonin derivative, which has an exocyclic C⁻C double bond, with p-bromophenyl nitrile oxide yielding only one spiroisoxazoline, has been studied within the molecular electron density theory ...
Luis R. Domingo   +2 more
doaj   +1 more source

(1S*,3R*,5S*,7S*)-4,4,8,8-Tetrachloro-1-isopropyl-5-methyltricyclo[5.1.0.03,5]octane

open access: yesActa Crystallographica Section E, 2014
The title compound, C12H16Cl4, is a derivative of the natural product 1-isopropyl-4-methylcyclohexa-1,4-diene, and represents a diastereomer with two trans-fused cyclopropane rings.
Koblandy M. Turdybekov   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Positive Integral Kernels for Polar Derivatives [PDF]

open access: yes, 2019
The non-negativity on the unit disk of the real part of the polar derivative of a polynomial is proved via an integral representation with a positive kernel, or as a consequence of a weighted sum of hermitian squares decomposition. 
Serguei Shimorin   +3 more
core   +1 more source

Zygmund’s Type Inequality to the Polar Derivative of a Polynomial [PDF]

open access: yesInternational Journal of Advanced Research in Mathematics, 2016
In this paper we improve a result recently proved by Irshad et al. [On the Inequalities Concerning to the Polar Derivative of a Polynomial with Restricted Zeroes, Thai Journal of Mathematics, 2014 (Article in Press)] and also extend Zygmund's inequality to the polar derivative of a polynomial.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Local Feature Extraction in Log-Polar Images [PDF]

open access: yes, 2015
We propose two different strategies to compute edges in the log-polar (cortical) domain. The space-variant processing is obtained by applying local operators (e.g.
CHESSA, MANUELA   +3 more
core   +1 more source

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