Results 91 to 100 of about 314,028 (293)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
(1S*,3R*,5S*,7S*)-4,4,8,8-Tetrachloro-1-isopropyl-5-methyltricyclo[5.1.0.03,5]octane
Acta Crystallographica Section E, 2014 The title compound, C12H16Cl4, is a derivative of the natural product 1-isopropyl-4-methylcyclohexa-1,4-diene, and represents a diastereomer with two trans-fused cyclopropane rings.
Koblandy M. Turdybekov +3 more
doaj +1 more source
Lifting smooth curves over invariants for representations of compact Lie groups, III
, 2005 Any sufficiently often differentiable curve in the orbit space $V/G$ of a real finite-dimensional orthogonal representation $G \to O(V)$ of a finite group $G$ admits a differentiable lift into the representation space $V$ with locally bounded derivative.
Kriegl, Andreas +3 more
core +4 more sources
Computation of the modes and polar moment of inertial of the blades of an HAWT [PDF]
, 1981 The coupled differential equations of motion of the blades of a horizontal axis wind turbine are solved numerically, permitting the optimization of the design at relatively low cost.
Beaulieu, G., Noiseux, D.
core +1 more source
Analyticity of the Susceptibility Function for Unimodal Markovian Maps of the Interval
, 2005 In a previous note [Ru] the susceptibility function was analyzed for some examples of maps of the interval. The purpose of the present note is to give a concise treatment of the general unimodal Markovian case (assuming $f$ real analytic).
Baladi V +7 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
General relativistic hydrodynamics in curvilinear coordinates
, 2014 In this paper we report on what we believe is the first successful implementation of relativistic hydrodynamics, coupled to dynamical spacetimes, in spherical polar coordinates without symmetry assumptions.
Baumgarte, Thomas W. +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Toward detailed prominence seismology - I. Computing accurate 2.5D magnetohydrodynamic equilibria
, 2011 Context. Prominence seismology exploits our knowledge of the linear eigenoscillations for representative magnetohydro- dynamic models of filaments. To date, highly idealized models for prominences have been used, especially with respect to the overall ...
Beliën +22 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source