Results 91 to 100 of about 854,777 (264)

Late Pleistocene fossil find in Svalbard: the oldest remains of a polar bear (Ursus maritimus Phipps, 1744) ever discovered [PDF]

open access: yes, 2009
During recent fieldwork in Svalbard, a well preserved subfossil left mandible of a polar bear (Ursus maritimus Phipps, 1774) was discovered. A 14C age determination shows that it is older than 45 Ky (kilo-years), and an age determination with infrared ...
Wiig, Øystein, Ingólfsson, Ólafur
core   +1 more source

(1S*,3R*,5S*,7S*)-4,4,8,8-Tetrachloro-1-isopropyl-5-methyltricyclo[5.1.0.03,5]octane

open access: yesActa Crystallographica Section E, 2014
The title compound, C12H16Cl4, is a derivative of the natural product 1-isopropyl-4-methylcyclohexa-1,4-diene, and represents a diastereomer with two trans-fused cyclopropane rings.
Koblandy M. Turdybekov   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Bernstein-Type Inequalities Involving Polar Derivative of a Polynomial

open access: yes, 2020
In this paper, we extend some polynomial inequalities to the polar derivative of a polynomial having all its zeros inside or outside a circle of radius k, k > 0 and thereby present some compact generalizations and improvements of certain well-known ...
Qasim, Idrees
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

The number and distribution of polar bears in the western Barents Sea [PDF]

open access: yes, 2017
Polar bears have experienced a rapid loss of sea-ice habitat in the Barents Sea. Monitoring this subpopulation focuses on the effects on polar bear demography.
Lone, Karen   +7 more
core  

The complex business of managing human activities and protecting the environment of the polar regions [PDF]

open access: yes, 2012
The thematic cluster ‘‘Human impacts in the Arctic and Antarctic’’ in Polar Research has its origins in the International Polar Year (2007-09) Oslo Science Conference held in Oslo, Norway, from 8 to 12 June 2010. We were the co-convenors of the session ‘‘
Liggett, Daniela   +5 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Decadal Changes of the Reflected Solar Radiation and the Earth Energy Imbalance

open access: yesRemote Sensing, 2019
Decadal changes of the Reflected Solar Radiation (RSR) as measured by CERES from 2000 to 2018 are analysed. For both polar regions, changes of the clear-sky RSR correlate well with changes of the Sea Ice Extent. In the Arctic, sea ice is clearly melting,
Steven Dewitte   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

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