Results 61 to 70 of about 76,947 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Application of M¨obius coordinate transformation in evaluating Newton’s integral

Contributions to Geophysics and Geodesy, 2011
We propose a numerical scheme which efficiently combines various existing methods of solving the Newton’s volume integral. It utilises the analytical solution of Newton’s integral for tesseroid in computing the near-zone contribution to gravitational ...
Robert TENZER, Vladislav GLADKIKH
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Computing the Fréchet Derivative of the Polar Decomposition

, 2016
We derive iterative methods for computing the Fréchet derivative of the map which sends a full-rank matrix $A$ to the factor $U$ in its polar decomposition $A=UH$, where $U$ has orthonormal columns and $H$ is Hermitian positive definite. The methods apply to square matrices as well as rectangular matrices having more rows than columns.
Gawlik, Evan S., Leok, Melvin
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

On the polar derivative of lacunary type polynomials

Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics
Let $p(z)=a_nz^n+\sum_{l=\nu}^na_{n-l}z^{n-l}$, where $1\leq \nu \leq n$, be a polynomial of degree $n$ having all its zeros in $|z|\leq k\leq 1$. For polar derivative $D_{\alpha}p(z)$, it is known that for each $|\alpha|\leq 1$ on $|z|=1$, \begin{align*} |D_{\alpha}p(z)|\leq \frac{n}{1+k^{\nu}}\Big\{(|\alpha|+k^{\nu})\|p\|_{\infty}-\frac{1 ...
Ahmad Motamednezhad, Fatemeh Mohammadi
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

INTEGRAL ANALOGUE OF TURÁN-TYPE INEQUALITIES CONCERNING THE POLAR DERIVATIVE OF A POLYNOMIAL

Ural Mathematical Journal
If \(w(\zeta)\) is a polynomial of degree $n$ with all its zeros in \(|\zeta|\leq \Delta, \Delta\geq 1\) and any real \(\gamma\geq 1\), Aziz proved the integral inequality [1] $$ \left\lbrace\int_{0}^{2\pi}\left|1+\Delta^ne^{i\theta}\right|^{\gamma}d ...
Mayanglambam Singhajit Singh, Barchand Chanam   +1 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the Chemoselectivity, Regioselectivity, and Diastereofacial Selectivity in the Synthesis of an Anticancer Spiroisoxazoline derived from α-Santonin

Molecules, 2019
The [3 + 2] cycloaddition (32CA) reaction of an α-santonin derivative, which has an exocyclic C⁻C double bond, with p-bromophenyl nitrile oxide yielding only one spiroisoxazoline, has been studied within the molecular electron density theory ...
Luis R. Domingo, Mar Ríos-Gutiérrez, Nivedita Acharjee   +2 more
doaj   +1 more source

Inequalities for the derivative and polar derivative of lacunary polynomials

Journal of Mathematical Inequalities
Summary: In this paper, we study lacunary polynomials of degree \(n\) having \(s\)-fold zeros at the origin and the remaining zeros lying on or outside the boundary of a prescribed disk. This study in turns gives generalizations and improvements of some well-known results.
Arunrat, Nuttapong, Nakprasit, Keaitsuda Maneeruk   +1 more
openaire   +2 more sources