Results 101 to 110 of about 314,270 (307)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Additional Rb-Sr and single-grain zircon datings of Caledonian granitoid rocks from Albert I Land, northwest Spitsbergen

, 1996
Previous K-Ar and Rb-Sr datings of the metamorphic and granitic rocks from the northwestern basement region of Spitsbergen mainly show the cooling time of the rocks, except for a Rb-Sr isochron age of the Hornemantoppen granitoid.
Balašov, Ju. A., Larionov, A. N., Peucat, J. J., Sirotkin, A. N., Teben'kov, A. M., Ohta, Y.   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Concepts of ferrovalley material and anomalous valley Hall effect

Nature Communications, 2016
Spontaneous polarization leads to various functionalities promising for future information storage and electronics. Here, the authors propose the concept of ferrovalley material with spontaneous valley polarization in monolayer 2H-VSe2.
Wen-Yi Tong, Shi-Jing Gong, Xiangang Wan, Chun-Gang Duan   +3 more
doaj   +1 more source

Seismic and radar investigations of Fourcade Glacier on King George Island, Antarctica

, 2010
To determine P- and S-wave velocities, elastic properties and subglacial topography of the polythermal Fourcade Glacier, surface seismic and radar surveys were conducted along a 470-m profile in November 2006.
Joohan Lee, Young Kim, Ki, Jong Kuk Hong, Kuk Hong, Jong, Ho Hong, Myung, Young Keun Jin, Ki Young Kim, Myung Ho Hong, Keun Jin, Young, Howong Shon, Lee, Joohan, Shon, Howong   +11 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

High-resolution electrical resistivity tomography applied to patterned ground, Wedel Jarlsberg Land, south-west Spitsbergen

, 2015
This article presents results of two-dimensional electrical resistivity tomography (ERT) applied to three types of patterned ground in Wedel-Jarlsberg Land (Svalbard), carried out in late July 2012. The structures investigated include sorted circles, non-
Marek Kasprzak, Kasprzak, Marek
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Ambient Moisture‐Induced Self Alignment of Polarization in Ferroelectric Hafnia

Advanced Science
The discovery of nanoscale ferroelectricity in hafnia (HfO2) has paved the way for next generation high‐density, non‐volatile devices. Although the surface conditions of nanoscale HfO2 present one of the fundamental mechanism origins, the impact of ...
Lu‐Qi Wei, Zhao Guan, Wen‐Yi Tong, Wen‐Cheng Fan, Abliz Mattursun, Bin‐Bin Chen, Ping‐Hua Xiang, Genquan Han, Chun‐Gang Duan, Ni Zhong   +9 more
doaj   +1 more source

Influence of composition on structure, morphology and dielectric properties of BixAlyOz composite films synthesized by atomic layer deposition

AIP Advances, 2017
In this experiment we used atomic layer deposited Bi2O3 and Al2O3 films to fabricate the BixAlyOz nanocomposite films. Bismuth composition was modulated in a series of samples via altering the number of bismuth subsidiary cycles.
Q. Qiao, L. P. Jin, Y. W. Li, M. J. Li, Z. G. Hu, J. H. Chu   +5 more
doaj   +1 more source