Results 41 to 50 of about 93,089 (301)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Do lulismo ao antipetismo? Polarização, partidarismo e voto nas eleições presidenciais brasileiras
Opinião PúblicaResumo O debate recente sobre identificação partidária e comportamento eleitoral no Brasil vem apontando para a crescente importância do posicionamento dos eleitores com respeito aos principais partidos presidenciais – PT e PSDB – na escolha dos ...
André Borges, Robert Vidigal
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Polarisation : the 'hyper-problem' transitional justice can no longer ignore [PDF]
As a 'hyper-problem' that makes political and social challenges harder to resolve, polarisation is both a barrier to addressing a violative past and a leading indicator of future risks of conflict and violence. Polarisation can decrease social cohesion,
Brankovic, Jasmina, Slye, Ronald C.
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
From polarity to plurality: Perceptions of COVID‐19 and policy measures in England and Scotland
Health ExpectationsAim The aim of this study was to uncover perspectives on the COVID‐19 pandemic and the responses implemented by the UK and Scottish Governments to help control the spread of infection. Such understanding could help to inform future responses to pandemics
Jack Rendall +4 more
doaj +1 more source
Tertium non datur? American Originalism and Polarization in Democracy [PDF]
Krytyka PrawaOriginalism – as one of the main approaches to the interpretation of the U.S. federal Constitution – has been increasingly viewed as an instrument of political struggle in the hands of the judiciary.
Katarzyna Maćkowska
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Spread of tweets in climate discussions: A case study of the 2019 Nobel Peace Prize announcement
Nordic Journal of Media Studies, 2021 Characterising the spreading of ideas within echo chambers is essential for understanding polarisation. In this article, we explore the characteristics of popular and viral content in climate change discussions on Twitter around the 2019 announcement of ...
Xia Yan +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source