Results 51 to 60 of about 93,089 (301)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Social InclusionPerceptions of societal polarisation in a country may influence individuals’ willingness to engage in non(normative) collective action. In the present research, we test the hypothesis that perceived societal polarisation reduces trust in the government ...
Rebekka Kesberg +3 more
doaj +1 more source
, 2001 A variable polarisation compensator has been designed and demonstrated experimentally at 100 GHz. The device uses two silicon plates with interlocking artificial dielectric surfaces to produce a birefringence that varies with the separation distance. The
Blaikie, R.J. +11 more
core +1 more source
Reflections on Emotions, Populism and Polarisation : HEPP2 Conference Proceedings [PDF]
, 2021 This volume hosts fifteen papers that bring together theoretical, case-based and thematic perspectives on populism, polarisation and emotions. It features proposals for theoretical and methodological innovations, as well as national and ...
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Trends in Polarisation in Pakistan [PDF]
, 2008 This study analyses the trends in polarisation in Pakistan, in its rural and urban segments and its provinces, at the micro level during the period 1992-93 to 2001-02.
Arshad, Haadia, Idrees, Muhammad
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Full-Stokes, Multi-Frequency Radio Polarimetry of Fermi Blazars; Monitoring and Modelling
Galaxies, 2017 The polarised emission from active galactic nuclei (AGN) jets carries information about the physical conditions at the emitting plasma elements, while its temporal evolution probes the physical processes that introduce variability and dynamically modify ...
Emmanouil Angelakis +2 more
doaj +1 more source