Results 41 to 50 of about 129,057 (205)

Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

open access: yeseLife, 2020
Neurons contain polarised microtubule arrays essential for neuronal function. How microtubule nucleation and polarity are regulated within neurons remains unclear.
Amrita Mukherjee   +4 more
doaj   +1 more source

Dissection of Arabidopsis ADP-Ribosylation Factor 1 function in epidermal cell polarity [PDF]

open access: yes, 2005
Vesicle trafficking is essential for the generation of asymmetries, which are central to multicellular development. Core components of the vesicle transport machinery, such as ADP-ribosylation factor (ARF) GTPases, have been studied primarily at the ...
Scheres, B.J.G.   +4 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Changes of cytoskeleton and polarity in cardiomyocyte-like cells derived from left ventricular noncompaction patients

open access: yesDi-san junyi daxue xuebao, 2021
Objective To investigate the changes and mechanism of the cytoskeleton and polarity in cardiomyocyte-like cells derived from patients with left ventricular noncompaction (LVNC). Methods After induced pluripotent stem cells (iPSCs) were isolated from LVNC
GUO Yun, GE Mei, LIU Aoyi, LYU Tiewei
doaj   +1 more source

Polarity-Driven Isomerization of a Hydroxynaphthalimide-Containing Spiropyran at Room Temperature

open access: yes, 2023
Design of spiropyrans showing spontaneous isomerization driven by the polarity of solvents is an important consideration for the synthesis of optical sensory materials.
Yasuhiro Shiraishi   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Polarity-Sensitive and Membrane-Specific Probe Quantitatively Monitoring Ferroptosis through Fluorescence Lifetime Imaging

open access: yes, 2022
As a new form of regulated cell death, ferroptosis is closely related to various diseases. To interpret this biological behavior and monitor related pathological processes, it is necessary to develop appropriate detection strategies and tools ...
Dingxuan Li (13200640)   +6 more
core   +1 more source

Tracking Brand-Associated Polarity-Bearing Topics in User Reviews [PDF]

open access: yes, 2023
Monitoring online customer reviews is important for business organizations to measure customer satisfaction and better manage their reputations. In this paper, we propose a novel dynamic Brand-Topic Model (dBTM) which is able to automatically detect and ...
Yulan He   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

open access: yeseLife, 2019
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues,
Daniel Čapek   +5 more
doaj   +1 more source

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