Results 61 to 70 of about 358,542 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell-cell Interaction, Cell Polarity, And The Blood-testis Barrier

, 2015
The study of polarity and its role in cell–cell interactions, such as spermatid polarity and adhesion in the seminiferous epithelium, and blood–testis barrier (BTB) in the testis during the epithelial cycle of spermatogenesis in recent years has yielded ...
Dolores D. Mruk, C. Yan Cheng, Will M. Lee, Tang, EIY, Lee, WWM, Cheng, CY, Mruk, DD, Elizabeth I. Tang   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Polarity-Reversal Strategy for the Functionalization of Electrophilic Strained Molecules via Light-Driven Cobalt Catalysis

, 2020
Strain-release-driven methodology is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutical industry. The reactivity of spring-loaded cyclic reagents is dominated by transformations relying on their inherent electrophilic
Michał Ociepa (5390465), Aleksandra J. Wierzba (3876586), Joanna Turkowska (3987800), Dorota Gryko (1428697)   +3 more
core   +3 more sources

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

eLife, 2019
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues,
Daniel Čapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg   +5 more
doaj   +1 more source

Dipole Moment‐ and Molecular Orbital‐Engineered Phosphine Oxide‐Free Host Materials for Efficient and Stable Blue Thermally Activated Delayed Fluorescence

Advanced Science, 2022
To utilize thermally activated delayed fluorescence (TADF) technology for future displays, it is necessary to develop host materials which harness the full potential of blue TADF emitters. However, no publication has reported such hosts yet. Although the
Soo‐Ghang Ihn, Daun Jeong, Eun Suk Kwon, Sangmo Kim, Yeon Sook Chung, Myungsun Sim, Jun Chwae, Yasushi Koishikawa, Soon Ok Jeon, Jong Soo Kim, Joonghyuk Kim, Sungho Nam, Inkoo Kim, Sangho Park, Dae Sin Kim, Hyeonho Choi, Sunghan Kim   +16 more
doaj   +1 more source

Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis

, 2014
Aditya Saxena was funded by the Cambridge Commonwealth Trust. Barry Denholm was funded by Kidney Research UK PDF1/2010. Stephanie Bunt was funded by The Rae and Edith Bennett Travelling Scholarship and John Stanley Gardiner Trust Fund.
Krishnaswamy VijayRaghavan, Helen Skaer, Barry Denholm. ¤b, Aditya Saxena. ¤a, Barry Denholm, Krishnaswamy Vijayraghavan Helen, Stephanie Bunt, Bunt, Stephanie, Skaer, Helen, VijayRaghavan, Krishnaswamy, Aditya Saxena, Marcus Bischoff, Bischoff, Marcus, Saxena, Aditya, Denholm, Barry   +14 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Apical/basal polarity : why plant cells do not stand on their heads

, 2005
The anatomical terminology that is used to describe the orientation and polarity in the plant body (for distinction indicated here in italics) is based on the consensus agreement that the transition zone between the aerial and the soil-borne part (the ...
Bennett, M., Grebe, Markus, Friml, J., Hejátko, Jan, Grebe, M., Torres-Ruiz, R., Grebe, Markus, Berleth, Thomas, Jürgens, Gerd, Luschnig, C., Heisler, Marcus, Weijers, D., Scheres, B.J.G., Offringa, Remko, Zažímalová, Eva, Berleth, T., Lukowitz, Wolfgang, Torres-Ruiz, Ramón, Friml, Jiří, Bennett, Malcolm, Lukowitz, Wolfgang, Benfey, P., Geldner, N., Scheres, Ben, Pattern and polarity in Arabidopsis root development, Torres-Ruiz, Ramón, Lukowitz, W., Laux, T., Dep Biologie, Bennett, Malcolm, Swarup, Raanjan, Luschnig, Christian, Geldner, Niko, Geldner, Niko, Laux, Thomas, Jürgens, Gerd, Scheres, B., Lindsey, K., Lindsey, Keith, Luschnig, Christian, Zazímalová, Eva, Hejátko, Jan, Swarup, Ranjan, Laux, Thomas, Benková, Eva, Berleth, Thomas, Zazímalová, E., Friml, Jirí, Hejato, J., Benfey, Philip, Juergens, G., Lindsey, Keith, Benfey, Philip, Benková, E., Weijers, Dolf, Grebe, Markus,, Weijers, Dolf, Jürgens, G., Benková, Eva, Heisler, Marcus, Offringa, R., Scheres, Ben, Hejátko, J., Offringa, Remko, Swarup, R., Heisler, M., Benfey, P.N.   +66 more
core   +1 more source