Results 71 to 80 of about 358,542 (314)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Improving Sentiment Polarity Detection Through Target Identification

, 2020
In an opinionated long review, there may be several targets described by different potential terms. Traditional review-level techniques for Persian sentiment analysis addressed the problem using a one-method-fits-all solution in which the overall ...
Abdar, Moloud, Kabiri, Arman, Nemati, Shahla, Yen, Neil Y., Allahbakhshi, Forough, Basiri, Mohammad Ehsan, Zhou, Xujuan   +6 more
core   +1 more source

Polarity-Sensitive Probe for Two-Photon Fluorescence Lifetime Imaging of Lipid Droplets In Vitro and In Vivo

, 2023
Lipid droplets (LDs) are crucial organelles used to store lipids and participate in lipid metabolism in cells. The abnormal aggregation and polarity change of LDs are associated with the occurrence of diseases, such as steatosis.
Xiuli Zheng, Jie Sha (3704722), Yuanyuan Qin (453405), Weimin Liu (50340), Yuanyuan Qin, Haohui Ren (9233178), Jie Sha, Weimin Liu, Jiasheng Wu (376682), Chun-Sing Lee (1293711), Wenjun Zhang (685002), Pengfei Wang (123133), Yimin Guo, Jiasheng Wu, Xiuli Zheng (4110463), Wenjun Zhang, Xuewei Li (112102), Chun-Sing Lee, Yimin Guo (11424445), Pengfei Wang, Xuewei Li, Haohui Ren   +21 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

A direct interaction of JAM-C with the tight junction scaffold protein ZO-2

Scientific Reports
Tight junctions are sites of cell-cell contacts at the apical region of epithelial junctions that are involved in barrier formation, cellular signaling, and cell-cell adhesion.
Annika Schulte, Mariel F. Schwietzer, Frauke Brinkmann, Valentin Teuber, Sandra Citi, Mikio Furuse, Michel Aurrand-Lions, Klaus Ebnet   +7 more
doaj   +1 more source

On negative Sprites and the Polarity Paradox

Geophysical Research Letters, 2019
Energetic positive and negative cloud‐to‐ground (CG) flashes are both capable of producing sprites. Negative CGs typically outnumber the positive ones by 10 to 1.
Alfred Bing‐Chih Chen, Han Chen, Chia‐Wen Chuang, Steven A. Cummer, Gaopeng Lu, Hui‐Kuan Fang, Han‐Tzong Su, Rue‐Ron Hsu   +7 more
doaj   +1 more source

Cell polarity: Par for the polar course [PDF]

Current Biology, 1997
The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.
Nelson, W.James, Grindstaff, Kent K.
openaire   +2 more sources

Polarity-Controlled GaN Epitaxial Films Achieved via Controlling the Annealing Process of ScAlMgO₄ Substrates and the Corresponding Thermodynamic Mechanisms

, 2018
Polarity-controlled GaN epitaxial films with Ga- and N-polarity are intentionally obtained by controlling annealing processes of ScAlMgO4 substrates.
Wenliang Wang (1233804), Yulin Zheng (1639588), Xiaochan Li (5491883), Yuan Li (67017), Ning Ye, Tao Yan (429415), Ning Ye (396809), Yuan Li, Guoqiang Li (417937), Tao Yan, Wenliang Wang, Xiaochan Li, Guoqiang Li, Yulin Zheng   +13 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

, 2017
The apical–basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear.
Meng, Anming, Ying Liu, Wang, Xiumei, Xiumei Wang, Xingfeng Liu, Yan, Xiyun, He, Rongqiao, Qian Gao, Wang, Zhaoqing, Rongqiao He, Gao, Qian, Liu, Ying, Yang, Dongling, Wang, Fei, Zhang, Junfeng, Liu, Xingfeng, Feng, Jing, Jing Feng, Fei Wang, Anming Meng, Dongling Yang, Junfeng Zhang, Zhaoqing Wang, Xiyun Yan   +23 more
core   +1 more source