Results 91 to 100 of about 737,468 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The polar code for patterning: how polarity and the cytoskeleton orchestrate asymmetric cell division during plant development

Frontiers in Cell and Developmental Biology
Cell polarity is fundamental to morphogenesis across living organisms. In plants, a dynamic interplay between polarity cues and the cytoskeleton orchestrates essential asymmetric cell divisions across diverse species.
Akanksha Garhewal, Gabriel J. Angres, Andrew Muroyama   +2 more
doaj   +1 more source

Dynamics of actin cables in polarized growth of the filamentous fungus Aspergillus nidulans

Frontiers in Microbiology, 2016
Highly polarized growth of filamentous fungi requires a continuous supply of proteins and lipids to the hyphal tip. This transport is managed by vesicle trafficking via the actin and microtubule cytoskeletons and their associated motor proteins ...
Anna eBergs, Yuji eIshitsuka, Minoas eEvangelinos, Minoas eEvangelinos, G. Ulrich eNienhaus, G. Ulrich eNienhaus, G. Ulrich eNienhaus, G. Ulrich eNienhaus, Norio eTakeshita, Norio eTakeshita   +9 more
doaj   +1 more source

Spectropolarimetric observations of an arch filament system with the GREGOR solar telescope

, 2016
Arch filament systems occur in active sunspot groups, where a fibril structure connects areas of opposite magnetic polarity, in contrast to active region filaments that follow the polarity inversion line.
Balthasar, H., Berkefeld, T., Denker, C., Feller, A., Gömöry, P., Hofmann, A., Kavka, J., Kuckein, C., Kučera, A., Lagg, A., Manrique, S. J. González, Nicklas, H., Rezaei, R., Schlichenmaier, R., Schmidt, D., Schmidt, W., Schwartz, P., Sigwarth, M., Sobotka, M., Solanki, S. K., Soltau, D., Staude, J., Strassmeier, K. G., Suárez, D. Orozco, Vašková, R., Vera, M. Collados, Volkmer, R., von der Lühe, O., Waldmann, T., Yabar, A. Pastor   +29 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Determination of the Critical Micelle Concentration of Triton X-100 Using the Compound 3-(benzoxazol-2-yl)-7-(N,N-diethylamino)chromen-2-one as Fluorescent Probe

Orbital: The Electronic Journal of Chemistry, 2016
In the present study we estimated the Critical Micelle Concentration (CMC) of Triton X-100 in an aqueous buffered medium (PBS buffer, pH 7.4), using 3-(benzoxazol-2-yl)-7-(N,N-diethylamino)chromen-2-one (BDC), a push-pull compound, as extrinsic ...
Antonio Eduardo da Hora Machado, Hueder Paulo Moisés de Oliveira, Lidiaine Maria dos Santos, Higor de Oliveira Alves, Werick Alves Machado, Bruno Pontes Caixeta, Tatiana Aparecida da Silva, Diesley Martins da Silva Araújo   +7 more
doaj   +3 more sources

Coronal hole boundaries at small scales: IV. SOT view Magnetic field properties of small-scale transient brightenings in coronal holes

, 2012
We study the magnetic properties of small-scale transients in coronal hole. We found all brightening events are associated with bipolar regions and caused by magnetic flux emergence followed by cancellation with the pre-existing and newly emerging ...
Doyle, J. G., Huang, Z., Lamb, D. A., Madjarska, M. S.   +3 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Towards Syntactic Iberian Polarity Classification

, 2017
Lexicon-based methods using syntactic rules for polarity classification rely on parsers that are dependent on the language and on treebank guidelines. Thus, rules are also dependent and require adaptation, especially in multilingual scenarios.
Alonso, Miguel A., Garcia, Marcos, Gómez-Rodríguez, Carlos, Vilares, David   +3 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source