Results 101 to 110 of about 737,468 (299)
Drug selection for inner ear therapy
Frontiers in PharmacologyIntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
'Just because' Constructions in Spoken and Written New Zealand English
Journal of Linguistics and Language Teaching, 2020 Just because (JB) is widely used and has been a target of commentary and humorous use by English speakers and aroused some interest among linguists, who have investigated its syntax, semantics, and derivation.
Andreea Calude, Gerald Delahunty
doaj
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Temporal-Polar Dynamics: Elevating Event-Based Micro-Expression Recognition
IEEE AccessMicro-expressions refer to brief, subtle facial movements often concealing genuine human emotions. However, the advancement of Micro-Expression Recognition (MER) is hindered by the low frame rates of frame-based cameras.
Junwu Lin, Cunhan Guo, Xiaofang Wu
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FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Signaling in Pollen Tube Growth: Beyond the Tip of the Polarity Iceberg
Plants, 2019 The coordinated growth of pollen tubes through floral tissues to deliver the sperm cells to the egg and facilitate fertilization is a highly regulated process critical to the Angiosperm life cycle.
Nolan Scheible, Andrew McCubbin
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, 2015 The interplanetary magnetic field near has a characteristic "sector" structure that reflects its polarity relative to the solar direction. Typically we observe large-scale coherence in these directions, with two or four "away" or "towards" sectors per ...
Hannah, Iain +2 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source