Results 81 to 90 of about 129,057 (205)

Dynamics of actin cables in polarized growth of the filamentous fungus Aspergillus nidulans

Frontiers in Microbiology, 2016
Highly polarized growth of filamentous fungi requires a continuous supply of proteins and lipids to the hyphal tip. This transport is managed by vesicle trafficking via the actin and microtubule cytoskeletons and their associated motor proteins ...
Anna eBergs, Yuji eIshitsuka, Minoas eEvangelinos, Minoas eEvangelinos, G. Ulrich eNienhaus, G. Ulrich eNienhaus, G. Ulrich eNienhaus, G. Ulrich eNienhaus, Norio eTakeshita, Norio eTakeshita   +9 more
doaj   +1 more source

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

, 2017
The apical–basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear.
Meng, Anming, Ying Liu, Wang, Xiumei, Xiumei Wang, Xingfeng Liu, Yan, Xiyun, He, Rongqiao, Qian Gao, Wang, Zhaoqing, Rongqiao He, Gao, Qian, Liu, Ying, Yang, Dongling, Wang, Fei, Zhang, Junfeng, Liu, Xingfeng, Feng, Jing, Jing Feng, Fei Wang, Anming Meng, Dongling Yang, Junfeng Zhang, Zhaoqing Wang, Xiyun Yan   +23 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Determination of the Critical Micelle Concentration of Triton X-100 Using the Compound 3-(benzoxazol-2-yl)-7-(N,N-diethylamino)chromen-2-one as Fluorescent Probe

Orbital: The Electronic Journal of Chemistry, 2016
In the present study we estimated the Critical Micelle Concentration (CMC) of Triton X-100 in an aqueous buffered medium (PBS buffer, pH 7.4), using 3-(benzoxazol-2-yl)-7-(N,N-diethylamino)chromen-2-one (BDC), a push-pull compound, as extrinsic ...
Antonio Eduardo da Hora Machado, Hueder Paulo Moisés de Oliveira, Lidiaine Maria dos Santos, Higor de Oliveira Alves, Werick Alves Machado, Bruno Pontes Caixeta, Tatiana Aparecida da Silva, Diesley Martins da Silva Araújo   +7 more
doaj   +3 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Polarity-Sensitive Probe for Two-Photon Fluorescence Lifetime Imaging of Lipid Droplets In Vitro and In Vivo

, 2023
Lipid droplets (LDs) are crucial organelles used to store lipids and participate in lipid metabolism in cells. The abnormal aggregation and polarity change of LDs are associated with the occurrence of diseases, such as steatosis.
Xiuli Zheng, Jie Sha (3704722), Yuanyuan Qin (453405), Weimin Liu (50340), Yuanyuan Qin, Haohui Ren (9233178), Jie Sha, Weimin Liu, Jiasheng Wu (376682), Chun-Sing Lee (1293711), Wenjun Zhang (685002), Pengfei Wang (123133), Yimin Guo, Jiasheng Wu, Xiuli Zheng (4110463), Wenjun Zhang, Xuewei Li (112102), Chun-Sing Lee, Yimin Guo (11424445), Pengfei Wang, Xuewei Li, Haohui Ren   +21 more
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Drug selection for inner ear therapy

Frontiers in Pharmacology
IntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

'Just because' Constructions in Spoken and Written New Zealand English

Journal of Linguistics and Language Teaching, 2020
Just because (JB) is widely used and has been a target of commentary and humorous use by English speakers and aroused some interest among linguists, who have investigated its syntax, semantics, and derivation.
Andreea Calude, Gerald Delahunty
doaj