Results 51 to 60 of about 737,468 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Development of electromagnetic tweezers for single-molecule energetics of kinesin

open access: yesBiophysics and Physicobiology
Optical tweezers have enabled single-molecule measurements of kinesin mechanics and energetics but face challenges for in vivo applications due to photothermal effects and refractive-index-dependent force calibration.
Haruyuki Fukuzawa   +7 more
doaj   +1 more source

POMPOMs: Cost-efficient polarity sensors for the MICE muon beamline [PDF]

open access: yes, 2011
Copyright @ 2011 The AuthorsThe cooling effect in MICE (Muon Ionisation Cooling Experiment) will be studied with both positive and negative muons, reversing the electrical input to the magnets by physically swapping over the power leads.
Hanlet, PM, Nebrensky, J
core  

Polarized Radicals [PDF]

open access: yesCell, 2013
Establishing polarized surfaces enables cells to carry out specialized tasks. In this issue, Lee et al. present a mechanism for cell polarization in which localized peroxidases are used to position the Casparian strip, a diffusion barrier deposited between endodermal cells in plant roots.
Liberman, Louisa M., Benfey, Philip N.
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

open access: yeseLife, 2019
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues,
Daniel Čapek   +5 more
doaj   +1 more source

Dipole Moment‐ and Molecular Orbital‐Engineered Phosphine Oxide‐Free Host Materials for Efficient and Stable Blue Thermally Activated Delayed Fluorescence

open access: yesAdvanced Science, 2022
To utilize thermally activated delayed fluorescence (TADF) technology for future displays, it is necessary to develop host materials which harness the full potential of blue TADF emitters. However, no publication has reported such hosts yet. Although the
Soo‐Ghang Ihn   +16 more
doaj   +1 more source

Polar Metallocenes [PDF]

open access: yesMolecules, 2019
Crystalline polar metallocenes are potentially useful active materials as piezoelectrics, ferroelectrics, and multiferroics. Within density functional theory (DFT), we computed structural properties, energy differences for various phases, molecular configurations, and magnetic states, computed polarizations for different polar crystal structures, and ...
Haiwu Zhang, B.Yu. Yavorsky, R.E. Cohen
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

open access: yes, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla   +58 more
core   +3 more sources

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