Results 71 to 80 of about 4,434,939 (302)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Polarization extinction ratio in polarization maintaining fiber sealed with glass solder

Научно-технический вестник информационных технологий, механики и оптики
The paper considers the effect of sealing with glass solder a pair of optical polarization maintaining fibers with an elliptical stress cladding on the value of the polarization extinction ratio.
E. E. Kalugin, A. B. Mukhtubaev, I. K. Meshkovskiy   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

1 GHz fundamental repetition rate thulium-doped all-polarization maintaining modelocked fiber laser

JPhys Photonics
In this work, we present a passively modelocked all-fiber laser that fully retains polarization with a fundamental repetition rate of 1 GHz. The whole cavity consists of a 106 mm-long highly-Tm-doped polarization-maintaining fiber with a dichroic mirror ...
C Cuadrado-Laborde, H Muñoz-Marco, P Pérez-Millán, A Díez-Cremades, J L Cruz, E Silvestre, M V Andrés   +6 more
doaj   +1 more source

SBS Mitigation by Manipulating the Injecting Polarization Direction in a High-Power Monolithic PM Amplifier

Photonics
The polarization direction-dependent SBS threshold was investigated, and the terminal polarization control technique was demonstrated to restore the linear polarization state.
Yu Wen, Chun Zhang, Chenxu Liu, Qiuhui Chu, Lingli Huang, Yuan Zhu, Haoyu Zhang, Rumao Tao, Honghuan Lin, Jianjun Wang   +9 more
doaj   +1 more source

Generation of stretched pulses from an all-polarization-maintaining Er-doped mode-locked fiber laser using nonlinear polarization evolution

Applied Physics Express, 2019
We demonstrate the generation of stretched pulses from an all-polarization-maintaining (all-PM) Er-doped fiber laser by means of a nonlinear polarization evolution (NPE) method.
Lian Zhou, Yang Liu, Ge-Hui Xie, Wen-Chao Zhang, Zhi-Wei Zhu, Cheng Ouyang, Cheng-Lin Gu, Wen-Xue Li   +7 more
semanticscholar   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cross-polarization coupling in polarization maintaining fiber induced by periodic mechanical stress

Научно-технический вестник информационных технологий, механики и оптики
One of the applications of polarization maintaining (PM) fibers is the creation of various sensors including level and hydrostatic pressure sensors. An external mechanical stress on a PM fiber causes cross-polarization coupling.
E. E. Kalugin, V. E. Strigalev, A. B. Mukhtubaev, I. K. Meshkovskii   +3 more
doaj   +1 more source

Two-Layer Polarization-Maintaining Solid-Core Photonic Crystal Fiber

IEEE Photonics Journal, 2018
In this study, a two-layer polarization-maintaining solid-core photonic crystal fiber (SC-PCF) is proposed. The cladding has two large holes both in the first and second layers for high birefringence and confinement loss reduction, respectively.
Ningfang Song, Fuyu Gao, Xiaobin Xu, Zhihao Zhang   +3 more
doaj   +1 more source

Investigation of dispersion-managed, polarization-maintaining Er-doped figure-nine ultrashort-pulse fiber laser.

Optics Express, 2019
Figure-nine fiber lasers can realize all-polarization-maintaining, self-started, highly stable mode-locked laser sources, and are very attractive for applications such as optical frequency combs, metrology, etc. In this work, we investigated a dispersion-
N. Nishizawa, Hayato Suga, M. Yamanaka
semanticscholar   +1 more source