Results 91 to 100 of about 86,994 (300)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, Volume 12, Issue 34, September 11, 2025.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Effect of Inactivated Poliovirus Vaccine Campaigns, Pakistan, 2014–2017

Emerging Infectious Diseases, 2018
Pakistan began using inactivated poliovirus vaccine alongside oral vaccine in mass campaigns to accelerate eradication of wild-type poliovirus in 2014.
Nicholas C. Grassly, Mufti Zubair Wadood, Rana M. Safdar, Abdirahman Sheikh Mahamud, Roland W. Sutter   +4 more
doaj   +1 more source

Reduced mucosal immunity to poliovirus after cessation of trivalent oral polio vaccine

Human Vaccines & Immunotherapeutics, 2021
The switch from using only trivalent oral polio vaccine (tOPV) to sequential schedules combining inactivated poliovirus vaccine (IPV) and bivalent oral polio vaccine (bOPV) for polio vaccination will cause changes to mucosal immunity against polio in ...
Ting Zhao, Jing Li, Hongyuan Shi, Hui Ye, Rufei Ma, Yuting Fu, Xiaochang Liu, Guoliang Li, Xiaolei Yang, Zhimei Zhao, Jingsi Yang   +10 more
doaj   +1 more source

Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell‐based, and genetic vaccines, with a focus on ...
Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Isolation and Identification of Polioviruses from Stool Specimens of Suspected Cases

Journal of Rawalpindi Medical College, 2014
Background: To study the isolation and identification of polioviruses from the stool specimen of suspected cases of poliomyelitis (polio). Methods : In this descriptive study two poliovirus-sensitive cell lines of human origin HEp-2, and RD were used for
Inaam Qadir J. Hashmi
doaj   +2 more sources

Potential for international spread of wild poliovirus via travelers

BMC Medicine, 2015
BackgroundThe endgame of polio eradication is hampered by the international spread of poliovirus via travelers. In response to ongoing importations of poliovirus into polio-free countries, on 5 May 2014, WHO’s Director-General declared the international ...
A. Wilder-Smith, W. Leong, L. F. Lopez, M. Amaku, M. Quam, K. Khan, E. Massad   +6 more
semanticscholar   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

MedComm, Volume 6, Issue 9, September 2025.
NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo, Cong Chen, Wenjing Zhou, Jianqi Hao, Song He, Yu Liu, Yin Ku, Linhua Huang, Chuanfen Zhang, Yueli Shu, Xiaoqing Wu, Yaojia Zhou, Jian Zhang   +12 more
wiley   +1 more source

Coverage, spatial distribution and determinants of childhood inactivated poliovirus vaccine immunization in Ethiopia.

PLoS ONE
IntroductionPolio eradication is a current and common strategy throughout the globe. The study of the newly introduced inactivated poliovirus vaccine provides a grasp on the current status of immunization and identifies any disparities in the ...
Tadesse Tarik Tamir, Belayneh Shetie Workneh, Enyew Getaneh Mekonen, Alebachew Ferede Zegeye   +3 more
doaj   +1 more source

Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response. [PDF]

PLoS Pathogens, 2010
Poliovirus is an enteric virus that rarely invades the human central nervous system (CNS). To identify barriers limiting poliovirus spread from the periphery to CNS, we monitored trafficking of 10 marked viruses.
Karen Z Lancaster, Julie K Pfeiffer
doaj   +1 more source