Prolonged Excretion of Poliovirus among Individuals with Primary Immunodeficiency Disorder: An Analysis of the World Health Organization Registry [PDF]
Frontiers in Immunology, 2017 Individuals with primary immunodeficiency disorder may excrete poliovirus for extended periods and will constitute the only remaining reservoir of virus after eradication and withdrawal of oral poliovirus vaccine.
Grace Macklin +31 more
doaj +4 more sources
Factors associated with the circulation of vaccine-derived polioviruses in children under five in Kilwa, Haut-Katanga province, Democratic Republic of Congo, 2022–2023 [PDF]
BMC Infectious DiseasesIntroduction Since the World Health Organization declared the African region free of wild poliovirus in August 2020, vaccine-derived polioviruses (VDPV) have remained the only form of poliovirus still circulating on the continent, including in the ...
Jean Blaise Yobo Iyala +7 more
doaj +2 more sources
Advances and challenges in poliomyelitis vaccines: a comprehensive review of development, production, and global deployment [PDF]
Frontiers in Public HealthPoliomyelitis has been a significant global health challenge for centuries. Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, remarkable progress has been achieved, with wild poliovirus (WPV) cases reduced by over 99%.
Jia Liang, Qi Zhang, Yanan Li, Lili Wang
doaj +2 more sources
Impediments to Progress Toward Polio Eradication During 2014–2024: Effectively Addressing the Current Challenges [PDF]
VaccinesWhen the Global Polio Eradication Initiative (GPEI) began in 1988, the year 2000 target was clearly ambitious. Nonetheless, among 20 countries with endemic wild poliovirus transmission in 2000, only Afghanistan, Nigeria and Pakistan remained endemic in ...
Steven G. F. Wassilak +2 more
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Poliomyelitis amidst the COVID-19 pandemic in Africa: Efforts, challenges and recommendations
Clinical Epidemiology and Global Health, 2022 Poliomyelitis is the leading infectious cause of acute flaccid paralysis among children under five years of age, caused by the Wild Poliovirus, with no medical cure other than prevention through vaccination.
Olivier Uwishema +7 more
doaj +1 more source
Reduced mucosal immunity to poliovirus after cessation of trivalent oral polio vaccine
Human Vaccines & Immunotherapeutics, 2021 The switch from using only trivalent oral polio vaccine (tOPV) to sequential schedules combining inactivated poliovirus vaccine (IPV) and bivalent oral polio vaccine (bOPV) for polio vaccination will cause changes to mucosal immunity against polio in ...
Ting Zhao +10 more
doaj +1 more source
Western Pacific Surveillance and Response, 2022 Objective: In response to an outbreak of circulating vaccine-derived poliovirus (cVDPV) type 2 in the Philippines in 2019–2020, several rounds of supplementary immunization activities using the monovalent type 2 oral poliovirus vaccine (OPV) were ...
SweetC B Alipon +12 more
doaj +1 more source
Frontiers in Immunology, 2023 The global polio eradication campaign has had remarkable success in reducing wild-type poliovirus infection, largely built upon the live attenuated Sabin oral poliovirus vaccine.
William Hywel Bermingham +8 more
doaj +1 more source
Importation and Circulation of Vaccine-Derived Poliovirus Serotype 2, Senegal, 2020–2021
Emerging Infectious Diseases, 2022 Environmental surveillance for poliovirus is increasingly used in poliovirus eradication efforts as a supplement to acute flaccid paralysis (AFP) surveillance. Environmental surveillance was officially established in 2017 in Senegal, where no poliovirus
Martin Faye +13 more
doaj +1 more source
Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape. [PDF]
, 2020 Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists.
Barton, John P +3 more
core +3 more sources