Results 41 to 50 of about 6,751,333 (339)
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
BMC Public Health, 2023 Background Intimate Partner Violence (IPV) is prevalent among HIV-infected men who have sex with men (MSM), with well-established risk factors and adverse outcomes. However, there is a lack of comprehensive investigation of both upstream risk factors and
Yong Yu +5 more
doaj +1 more source
False Idles: The Politics of the "Quiet Life" [PDF]
, 2008 The dominant Greek and Roman ideology held that the best human life required engaging in politics, on the grounds that the human good is shared, not private, and that the activities central to this shared good are those of traditional politics.
Brown, Eric
core
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
Human Security and the Special Autonomy
Bestuurskunde, 2022 Issues of human rights violations, poverty, unemployment, low HDI, low access to education, and poor health are the most important parts of the concept of human security introduced by the UNDP report 1994. These issues have not been adequately addressed
Hendy Setiawan, Khalimatus Sa’diyah
doaj +1 more source
Contested Terrain: Understanding The Persistence Of Racial Inequality In America [PDF]
, 1999 Review Of The Color Of Politics: Race And The Mainsprings Of American Politics By M. Goldfield, Facing Up To The American Dream By J. Hochschild, Shifting The Color Line: Race And The American Welfare State By R.C. Lieberman, Voting Hopes Or Fears?
Nackenoff, Carol
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
What Does It Take for Immigrants to Join Political Parties?
Politics and GovernancePolitical parties are crucial agents in democratic representation and political integration of persons of immigrant origin, a growing category of citizens in the European Union.
Monika Bozhinoska Lazarova +2 more
doaj +1 more source
Democracy, Race, and Multiculturalism in the Twenty-First Century: Will the Voting Rights Act Ever be Obsolete? [PDF]
, 2006 Part I of this essay begins one hundred years before the passage of the Act, with Reconstruction. I briefly canvas the interracial alliances of the Reconstruction and Redemption periods, underscoring that American democracy has been most responsive to ...
Cashin, Sheryll
core +2 more sources