Results 91 to 100 of about 731 (213)

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

A Plant-Derived Antifungal Agent, Poacic Acid, Inhibits Germination and Tube Growth of Lily Pollen

Plants
Poacic acid is a novel natural antifungal agent. It inhibits the growth of fungal cells, including budding yeast Saccharomyces cerevisiae, by inhibiting the synthesis of β-1,3-glucan, which is a major component of the fungal cell wall.
Nanami Kobayashi, Yoshikazu Ohya, Yasuko Hayashi, Shuh-ichi Nishikawa   +3 more
doaj   +1 more source

Distinct Immunometabolic Profiles in Finnish and Russian Karelian Adolescents With Contrasting Allergy Risk

Allergy, EarlyView.
We compared Finnish and Russian Karelian adolescents with contrasting allergy burden using integrated proteomic, metabolomic, and transcriptomic profiling. Finnish adolescents showed a broader pro‐inflammatory PBMC secretory profile consistent with a low‐grade inflammatory phenotype.
Nanna Fyhrquist, Matilda Riskumäki, Piia Karisola, Anni Nieminen, Tiina Laatikainen, Hanna Sinkko, Laura Paalanen, Pekka Jousilahti, Erkki Vartiainen, Mika J. Mäkelä, Tari Haahtela, Harri Alenius   +11 more
wiley   +1 more source

Organelle trafficking, the cytoskeleton, and pollen tube growth

Journal of Integrative Plant Biology, 2014
AbstractThe pollen tube is fundamental for the reproduction of seed plants. Characteristically, it grows relatively quickly and uni‐directionally (“polarized growth”) to extend the male gametophyte to reach the female gametophyte. The pollen tube forms a channel through which the sperm cells move so that they can reach their targets in the ovule.
Cai, Giampiero, PARROTTA, LUIGI, Cresti, Mauro   +2 more
openaire   +5 more sources

Influence of Environmental Pollution on Basophil Reactivity to Birch Pollen Allergens in Atopic and Non‐Atopic Subjects

Allergy, EarlyView.
Birch pollen and PM10 are key determinants of clinical symptoms, particularly in asthma. Allergic people react stronger to the pollen collected in the highly polluted area than in the less polluted areas. When evaluating the effectiveness of allergen immunotherapy, it is essential to consider not only pollen concentrations but also levels of air ...
Maria Czarnobilska, Małgorzata Bulanda, Ewa Czarnobilska, Wojciech Dyga, Marek Jutel, Dorota Myszkowska   +5 more
wiley   +1 more source

Response of Remote Tropical West Pacific Islands to Climate Variability: A Multiproxy Record From T‐Lake, Palau, Spanning the Early Holocene to Present

Archaeometry, EarlyView.
ABSTRACT Lake sediments are natural archives of past environmental dynamics and how these systems have responded to past climate variability. Sediment geochemistry, governed by local geology and climate processes, is unique to each lake‐catchment and geochemical proxies must be validated for each study site.
Jalene Nalbant, Larissa Schneider, Jessica L. Blois, Matthew Wolhowe, Julian P. Sachs, Simon G. Haberle, Geoffrey Clark   +6 more
wiley   +1 more source

Towards an ‘absolute’ timing of biostratigraphic and environmental phases from the Saalian late glacial to the Weichselian pleniglacial in central Europe—Insights from a lacustrine succession in Lichtenberg, northern Germany

Boreas, EarlyView.
Palynological records are central to the biostratigraphic subdivision of the Late Pleistocene in central Europe. Yet many interglacial and interstadial phases—such as the Eemian, Brörup and Odderade—remain only poorly constrained in time due to limited numerical dating.
Michael Hein, Thomas Kasper, Alexis Badai Samudra, Martin Theuerkauf, Markus Lothar Fischer, Neda Rahimzadeh, Maria Sekar Proborukmi, Sonja Rigterink, Agnieszka Gruszczyńska, Christian Zeeden, Simon Parfitt, David John Horne, Lucy Roberts, Dustin White, Lisa Brogmus, Hans von Suchodoletz, Tobias Lauer, Marcel Weiss, David Colin Tanner, Brigitte Urban   +19 more
wiley   +1 more source

Changes in land‐snail communities and steppe environments in the lower Rhône valley during the Lateglacial–Holocene transition

Boreas, EarlyView.
Land snail successions in the lower Rhône valley allow us to reconstruct the postglacial recolonization. From the Lateglacial period onwards, Mediterranean steppe communities appeared. The arrival of forest taxa was significantly delayed by aridity. The question of glacial refugia, both local and distant, primarily concerned Mediterranean species of ...
Frédéric Magnin
wiley   +1 more source

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source