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Polo-like kinase-1 is a target of the DNA damage checkpoint
Nature Cell Biology, 2000Polo-like kinases (PLKs) have an important role in several stages of mitosis. They contribute to the activation of cyclin B/Cdc2 and are involved in centrosome maturation and bipolar spindle formation at the onset of mitosis. PLKs also control mitotic exit by regulating the anaphase-promoting complex (APC) and have been implicated in the temporal and ...
Smits, V. A. +5 more
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Polo-like kinase 1 is essential to DNA damage recovery
Leukemia & Lymphoma, 2010Radiation treatment and chemotherapy can both cause DNA damage to tumor cells. Tumor cells have specific self-protecting mechanisms to escape death. In this study, we explored the effects of polo-like kinase 1 on the DNA damage recovery system in lymphoma cell lines.
Lin, Liu, Min, Zhang, Ping, Zou
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Polo-Like Kinase 1 as a Potential Therapeutic Target for Osteosarcoma
Current Pharmaceutical Design, 2015Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. Existing treatment options and surgical intervention are unable to effectively manage this tumor. Therefore, novel mechanism-based targets and strategies need to be rationally established to strive for improvement in the survival of patients diagnosed with ...
Li, Cheng +2 more
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Developing Polo-like Kinase 1 Inhibitors
Future Medicinal Chemistry, 2020Xufeng Huang +2 more
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Targeting polo‐like kinase 1 to treat kidney diseases
Cell Biochemistry and FunctionAbstractGlobally, ∼850 million individuals suffer from some form of kidney disease. This staggering figure underscores the importance of continued research and innovation in the field of nephrology to develop effective treatments and improve overall global kidney health.
Hrushikesh Kulkarni +2 more
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Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications
Journal of Drug Targeting, 2021Mohammad Afzal +2 more
exaly
Small-molecule Inhibitors for Targeting polo-like Kinase 1
Future Medicinal Chemistry, 2020Iryna Kolosenko, Caroline Palm-Apergi
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Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction
International Journal for Parasitology, 2010Katia Cailliau +2 more
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