Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]
PharmaceuticsBackground/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
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Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs [PDF]
PharmaceuticalsBackground: Surfactants can be added into polymer–amorphous drug systems to further enhance solubility. However, this may cause amorphous drugs to become physically unstable, and the inherent mechanism at play here is not fully understood.
Jie Zhang +13 more
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In Situ Gel Containing Lippia sidoides Cham. Essential Oil for Microbial Control in the Oral Cavity [PDF]
MicroorganismsSurgical site infections in oral and maxillofacial interventions are often exacerbated by biofilm formation, and current antimicrobial treatments are hampered by issues such as resistance and adverse effects.
Maria Vitoria Oliveira Dantas +9 more
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Investigation of Rheological Characteristics of Thermosensitive Nasal In Situ Gels Based on P407 and Their Effect on Spray Pattern [PDF]
GelsThis article presents the results of a study on the rheological characteristics of in situ thermosensitive nasal gels based on poloxamer 407 (P407) and their effect on spray angle.
Natalia Menshutina +3 more
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Use of factorial design in formulation and evaluation of intrarectal in situ gel of sumatriptan
Journal of Advanced Pharmaceutical Technology & Research, 2023 The study's goal was to create an in situ intrarectal mucoadhesive gel of sumatriptan (SMT) combining mucoadhesive polymer (xyloglucan) and thermosensitive polymers (poloxamer 407 and poloxamer 188) to prolong rectal residence time for treatment of ...
Hanan J Kassab +2 more
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Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery
Brazilian Journal of Pharmaceutical Sciences, 2023 Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs.
Dwianto Harry Nugraha +2 more
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Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole
Pharmaceutics, 2023 Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs.
Jie Zhang +10 more
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Efficient chemotherapy of rat glioblastoma using Doxorubicin-loaded PLGA nanoparticles with different stabilizers [PDF]
, 2011 Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain.
Wohlfart, Stefanie +6 more
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Nanogels for pharmaceutical and biomedical applications and their fabrication using 3D printing technologies [PDF]
, 2018 Nanogels are hydrogels formed by connecting nanoscopic micelles dispersed in an aqueous medium, which give an opportunity for incorporating hydrophilic payloads to the exterior of the micellar networks and hydrophobic payloads in the core of the micelles.
Cho, Hyunah +2 more
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Preparation of injectable sodium alginate/ poloxamer composite hydrogel for sustained drug release
Cailiao gongcheng, 2020 Poloxamer is a thermo-sensitive synthetic polymer that can achieve sol-gel transition with temperature change, but its relative molecular mass is low, and the hydrogel structure is difficult to maintain for a long time.
HOU Bing-na +6 more
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