Results 91 to 100 of about 22,356 (221)

In vitro IFN-α release from IFN-α- and pegylated IFN-α-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-co-glycolic acid) nanoparticles [PDF]

, 2016
Aim: Interferon alpha (IFN-α) controlled release of nanoparticles was investigated under in vitro conditions. Materials & methods: IFN-α and pegylated IFN-α (PEG-IFN-α) were encapsulated by poly(lactic-co-glycolic acid) (PLGA) and pegylated PLGA ...
Feczkó, Tivadar, Fodorné Kardos, Andrea, Shubhra, Quazi T. H., Sivakumaran, Muttuswamy   +3 more
core   +1 more source

PEGylated Chitosan Nanoparticles: Engineering Multifunctional Platforms for Targeted Cervical and Lung Cancer Treatment

Cancer Science, EarlyView.
Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani, Nazim Nasir, Shadma Wahab, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Development and Characterization of Thermosensitive and Bioadhesive Ophthalmic Formulations Containing Flurbiprofen Solid Dispersions

Gels
In this study, we aimed to develop thermosensitive and bioadhesive in situ gelling systems containing solid dispersions of flurbiprofen (FB-SDs) using poloxamer 407 (P407) and 188 (P188) for ophthalmic delivery.
Pınar Adısanoğlu, Işık Özgüney
doaj   +1 more source

Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice [PDF]

, 2003
Objective: To study the toxicity and activity of two new amphotericin B formulations: poly(ε-caprolactone) nanospheres coated with poloxamer 188 (AmB-NP) and mixed micelles with the same surfactant (AmB-MM). Materials and methods: The toxicity of these
Appel, M. (M.), Barratt, G. (G.), Campanero, M.A. (Miguel Angel), Cheron, M. (M.), Espuelas, S. (Socorro), Gamazo, C. (Carlos), Irache, J.M. (Juan Manuel), Legrand, P. (P.)   +7 more
core   +1 more source

Diurnal and nocturnal salivary fluoride bioavailability following brushing with high‐ or regular‐fluoride dentifrices

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated salivary fluoride (F) bioavailability during diurnal and nocturnal periods after using a high‐fluoride or regular dentifrice. Fifteen healthy adults participated in a double‐blind crossover study, brushing with either a 1450 ppm F or 5000 ppm F dentifrice.
Guereth Carvalho, Guilherme Santana, Niciane Macena, Gláuber Vale   +3 more
wiley   +1 more source

Development of a Mucoadhesive In Situ Gelling Formulation for the Delivery of Lactobacillus gasseri into Vaginal Cavity

Pharmaceutics, 2019
Local administration of vaginal probiotics, especially lactobacilli, has been recently proposed as an effective prevention strategy against candidosis recurrences, which affect 40−50% of women.
Barbara Vigani, Angela Faccendini, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Pietro Grisoli, Franca Ferrari   +6 more
doaj   +1 more source

Wettability of saliva substitutes across various denture base fabrication techniques

Journal of Prosthodontics, EarlyView.
Abstract Purpose The present study evaluated the contact angles (CAs) of four denture base materials subjected to different surface treatments using deionized water and saliva substitutes. Material and Methods A total of 32 rectangular specimens were manufactured using four different denture base materials: heat‐cured compression molded Lucitone 199 (C)
Paul Mikhail, Igor Pesun, Francisco Azpiazu‐Flores, Rodrigo França   +3 more
wiley   +1 more source

Microneedle System Coated with Hydrogels Containing Protoporphyrin IX for Potential Application in Pharmaceutical Technology

Methods and Protocols
The article aims to outline the potential of treating malignant skin cancer with microneedles covered with polymer layers containing a photosensitizer—protoporphyrin IX disodium salt (PPIX).
Beata Czarczynska-Goslinska, Tomasz Goslinski, Agata Roszak, Anna Froelich, Piotr Szyk, Dariusz T. Mlynarczyk, Lukasz Sobotta, Irena Budnik, Oliwia Kordyl, Tomasz Osmałek   +9 more
doaj   +1 more source

Gentamicin-loaded microspheres for reducing the intracellular Brucella abortus load in infected monocytes [PDF]

, 2017
Objectives: The intracellular antibiotic efficiency of gentamicin-loaded microspheres in the context of Brucella-infected murine monocytes was examined in vitro with a view to developing improved therapies for the treatment of brucellosis.
Gamazo, Carlos, Gander, Bruno, Irache, Juan M., Lecároz, Concepción, Prior, Sandra   +4 more
core  

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source