Results 101 to 110 of about 22,356 (221)

Design and development of thermosensitive rectal in situ gel from Luffa acutangula fruits for the treatment of ulcerative colitis

Journal of Applied Pharmaceutical Research
Background: Luffa acutangula has good anti-inflammatory and antioxidant activity.  Ulcerative colitis has inflamed intestinal mucosal lining with frequent diarrhoea, mucosal, and bloody stools.
Swati P. Barangule, Avish D. Maru
doaj   +1 more source

Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions [PDF]

, 2016
BACKGROUND: The aims of this study were to evaluate the effect of poloxamer 407 administration on atherogenic serum lipoprotein fractions and subfractions associated with cholesterol, triglycerides and phospholipids, as well as the onset of early ...
Alexandr B. Pupyshev, Fedor V. Tuzikov, Igor V. Maiborodin, Natalia A. Tuzikova, Natalia A. Zhukova, Natalya V. Goncharova, Tatyana A. Korolenko, Thomas P. Johnston, Victor K. Spiridonov   +8 more
core   +1 more source

New Integrative Vectors Increase Agrobacterium rhizogenes Transformation and Help Characterise Roles for Soybean GmTML Gene Family Members

Plant, Cell &Environment, EarlyView.
ABSTRACT Hairy‐root transformation is widely used to generate transgenic plant roots for genetic functional characterisation studies. However, transformation efficiency can be limited, largely due to the use of binary vectors. Here, we report on the development of novel integrative vectors that significantly increase the transformation efficiency of ...
Huanan Su, Mengbai Zhang, Estelle B. Grundy, Brett J. Ferguson   +3 more
wiley   +1 more source

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

Pharmaceutics, 2019
The self-assembly phenomenon of amphiphiles has attracted particular attention in recent years due to its wide range of applications. The formation of nanoassemblies able to solubilize sparingly water-soluble drugs was found to be a strategy to solve the
Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Mateusz Kurek, Karolina Gawlak, Joanna Odrobińska, Marian Paluch, Renata Jachowicz   +8 more
doaj   +1 more source

Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances [PDF]

, 2014
YesThis mini-review highlights the latest advances in the chemistry and biology of Pluronic® triblock copolymers. We focus on their applications in medicine, as drug delivery carriers, biological response modifiers, and pharmaceutical ingredients ...
Acharya, Alakhova, Alakhova, Alexandridis, Alivisatos, Anaïs Pitto-Barry, Andrews, Bangham, Bareford, Barry, Barry, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Bissery, Boyd, Boyd, Brown, Cervin, Chen, Chen, Chong, Collet, Drummond, Engstrom, Fan, Gariepy, Gelderblom, Gref, Gucu, Höfig, Jiang, Jokerst, Kabanov, Kabanov, Kamaly, Kirtane, Konno, Kurahashi, Lee, Liu, Malmsten, Minko, Moghaddam, Neumann, Nicolas P. E. Barry, Oh, Schmolka, Steinbach, Uyama, Valle, Venne, Wang, Watson, Weiss, Wu, Xing, Yaghmur, Yuk, Zhou   +63 more
core   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Mucus-penetrating solid lipid nanoparticles for the treatment of cystic fibrosis : proof of concept, challenges and pitfalls

, 2018
Nanocarrier-mediated transmucosal drug delivery based on conventional mucoadhesive, muco-inert or mucus penetrating nanoparticles (NPs) is a growing field especially in challenging diseases like cystic fibrosis (CF).
Braeckmans, Kevin, Forier, Katrien, Nafee, N, Schneider, M   +3 more
core   +1 more source

Pegylated lipid nanocapsules with improved drug encapsulation and controlled release properties [PDF]

, 2014
Drugs with poor lipid and water solubility are some of the most challenging to formulate in nanocarriers, typically resulting in low encapsulation efficiencies and uncontrolled release profiles.
Alonso Fernández, María José, Alonso-Sande, Maria, García-Fuentes, Marcos, Hervella, Pablo, Ledo, Francisco, Lucero, Maria L.   +5 more
core   +1 more source

Delivery of AgNP led to more pronounced local retention in the subcutaneous versus intraperitoneal location with limited uptake and toxic effects in rats

Veterinary Surgery, EarlyView.
Abstract Objective To determine adverse effects of intraperitoneally (IP) or subcutaneously (SC) delivered silver nanoparticles (AgNP) in poloxamer 407 (P407; AgNP‐P407) and local retention and systemic uptake in rats. Study design Controlled randomized trial. Animals A total of 25 rats. Methods A total of 10 rats were randomly assigned in Phase 1 to a
Marije Risselada, Makensie L. Anderson, Miriam G. Bates, Abigail Cox, Robyn McCain, Kristen Messenger   +5 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source