Results 51 to 60 of about 11,077 (197)

Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

Molecules, 2015
The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and ...
Prabagar Balakrishnan, Eun-Kyoung Park, Chung-Kil Song, Hyun-Jeong Ko, Tae-Wook Hahn, Ki-Won Song, Hyun-Jong Cho   +6 more
doaj   +1 more source

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

Molecules, 2019
The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability of poorly ...
Serena Bertoni, Beatrice Albertini, Nadia Passerini   +2 more
doaj   +1 more source

Synthesis of PAMAM-Poloxamer Dendrimers and in vitro Test as a Drug Carrier

工程科学与技术, 2011
:Polymeric drug delivery systems are used to improve aqueous solubility and photostability. Camptothecin (CPT) is a plant alkaloid that is practically insoluble in water and photosensitive.
Ma Li-fang, 王宇飞, 郭丽
doaj  

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

Beilstein Journal of Nanotechnology
Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic analysis.
Mazhar Hussain, Muhammad Farooq, Muhammad Asad Saeed, Muhammad Ijaz, Sherjeel Adnan, Zeeshan Masood, Muhammad Waqas, Wafa Ishaq, Nabeela Ameer   +8 more
doaj   +1 more source

Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles

Gels
Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor.
Ana Camila Marques, Paulo C. Costa, Sérgia Velho, Maria Helena Amaral   +3 more
doaj   +1 more source

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, EarlyView.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source

Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues

Molecules, 2018
Ceragenins were designed as non-peptide mimics of endogenous antimicrobial peptides, and they display broad-spectrum antibacterial and antifungal activities, including the ability to eradicate established biofilms.
Marjan M. Hashemi, Brett S. Holden, Maddison F. Taylor, John Wilson, Jordan Coburn, Brian Hilton, Tania Nance, Shawn Gubler, Carl Genberg, Shenglou Deng, Paul B. Savage   +10 more
doaj   +1 more source

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid

Nanomaterials, 2020
Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties.
Maddalena Sguizzato, Paolo Mariani, Francesca Ferrara, Markus Drechsler, Supandeep Singh Hallan, Nicolas Huang, Fanny Simelière, Nikul Khunti, Rita Cortesi, Nicola Marchetti, Giuseppe Valacchi, Elisabetta Esposito   +11 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source