Results 61 to 70 of about 16,153 (200)

Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

Molecules, 2015
The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and ...
Prabagar Balakrishnan, Eun-Kyoung Park, Chung-Kil Song, Hyun-Jeong Ko, Tae-Wook Hahn, Ki-Won Song, Hyun-Jong Cho   +6 more
doaj   +1 more source

Enhancing Lentiviral Purification: Combining CIM QA Monolithic Columns With Design of Experiments Approach

ELECTROPHORESIS, EarlyView.
Lentiviral vector purification using QA CIM monolith anion‐exchange chromatography was optimized via 96‐well and DOE, increasing recovery from 20% to 90%. The process achieved 3.3‐log host cell protein reduction, decreased particle impurities, and showed high binding capacity, supporting large‐scale manufacturing.
Luka Bevc, Ana Pavšič Rijavec, Valentina Novak, Sandra Potušek Šuleski, Ivana Petrović Koshmak, Maja Leskovec, Hana Jug, Aleš Štrancar   +7 more
wiley   +1 more source

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

Molecules, 2019
The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability of poorly ...
Serena Bertoni, Beatrice Albertini, Nadia Passerini   +2 more
doaj   +1 more source

Evaluation of Poloxamer as a Slow Release Carrier for Morphine

, 2017
This study evaluates the use of poloxamer as a slow release carrier for morphine to prolong its duration of effect. The thermoresponsive nature of poloxamer enables it to be injected in solution, and form a drug depot once it gels in the patient.
Sulimai, Nurul Hudah
core   +1 more source

Synthesis of PAMAM-Poloxamer Dendrimers and in vitro Test as a Drug Carrier

工程科学与技术, 2011
:Polymeric drug delivery systems are used to improve aqueous solubility and photostability. Camptothecin (CPT) is a plant alkaloid that is practically insoluble in water and photosensitive.
Ma Li-fang, 王宇飞, 郭丽
doaj  

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

Beilstein Journal of Nanotechnology
Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic analysis.
Mazhar Hussain, Muhammad Farooq, Muhammad Asad Saeed, Muhammad Ijaz, Sherjeel Adnan, Zeeshan Masood, Muhammad Waqas, Wafa Ishaq, Nabeela Ameer   +8 more
doaj   +1 more source

Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles

Gels
Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor.
Ana Camila Marques, Paulo C. Costa, Sérgia Velho, Maria Helena Amaral   +3 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

Properties of poloxamer molecules and poloxamer micelles dissolved in water and next to lipid bilayers : results from computer simulations

, 2016
To study the properties of poloxamer molecules P85 and P188 and micelles containing these poloxamers in bulk water and also next to lipid bilayers, we performed coarse-grained molecular dynamics computer simulations.
Goliaei, A., Tsereteli, L., Adhikari, U., Berkowitz, M.   +3 more
core   +1 more source

Transparent Surfactant‐Based Isotropic Systems for Topical Co‐Delivery of Hydrophilic and Lipophilic Actives for Striae Distensae

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT Striae distensae are common dermal lesions that negatively affect skin appearance, and topical management remains limited by challenges related to skin deposition and residence time. Here, we developed transparent surfactant‐based isotropic systems for the topical co‐delivery of ascorbic acid (AA), retinoic acid (RA), and lavender essential ...
Claudiane Ayres Prochno, Anna Paula Brusamarello, Anna Cláudia Morais de Oliveira Capote, Thais Leticia Moreira da Silva, Gabriela Ruva Fagundes, Giovani Marino Favero, Marina Tolentino Marinho, Benjamim Melo de Carvalho, Priscileila Colerato Ferrari   +8 more
wiley   +1 more source