Results 61 to 70 of about 22,356 (221)

New Biopharmaceutical Characteristics of In Situ Systems Based on Poloxamer 407

Gels, 2023
Thermosensitive systems based on poloxamer 407 are widely used in targeted drug delivery; however, the stability of the phase transition temperature remains insufficiently studied.
Elena O. Bakhrushina, Elizaveta V. Novozhilova, Marina M. Shumkova, Victor S. Pyzhov, Maria S. Nikonenko, Alexander I. Bardakov, Natalia B. Demina, Ivan I. Krasnyuk, Ivan I. Krasnyuk   +8 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes

Molecules, 2023
Vaccine technology is still facing challenges regarding some infectious diseases, which can be addressed by innovative drug delivery systems. In particular, nanoparticle-based vaccines combined with new types of adjuvants are actively explored as a ...
Myriam Lamrayah, Capucine Phelip, Renaud Rovera, Céline Coiffier, Nora Lazhar, Francesca Bartolomei, Evelyne Colomb, Bernard Verrier, Claire Monge, Sophie Richard   +9 more
doaj   +1 more source

Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations : design, characterisation, toxicity and transcorneal permeation studies [PDF]

, 2017
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-
Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abou El-elaa, Ajit, Al Khateb, Alany, Almeida, Amal K. Hussein, Angius, Anil Vangala, Asasutjarit, Attama, Auerbach, Baeyens, Baklayan, Baloglu, Chena, Dohle, Dumortier, El-Kamel, Faber, Fathalla, Fernández-Ferreiro, Garg, Gupta, Hao, Heilmann, Kadam, Khaled A. Khaled, Kim, Kim, Law, Li, Ling, Luepke, Mansour, Mayol, Michael Longman, Mosmann, Mythri, Nanjawade, Nanjwadea, Newa, Omar H. El-Garhy, Qi, Raid G. Alany, Riccia, Rooks, Rossi, Rupenthal, Rupenthala, Schoenwald, Sinha, Sintzel, Sunil, Thakor, Thrimawithana, Thrimawithanaa, Vadnere, Verstraelen, Walters, Wei, Weterings, Worakul, Xu, Yang, Zeinab M.A. Fathalla   +72 more
core   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice

BMC Cardiovascular Disorders, 2011
Background Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients. The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle.
Sali Arpana, Yu Qing, Guerron Alfredo D, Spurney Christopher F, van der Meulen Jack H, Hoffman Eric P, Nagaraju Kanneboyina   +6 more
doaj   +1 more source

Development and optimization of amphiphilic self-assembly into nanostructured liquid crystals for transdermal delivery of an antidiabetic SGLT2 inhibitor

Drug Delivery, 2022
The anti-hyperglycemic sodium glucose co-transporter 2 inhibitor Canagliflozin (CFZ) represents a recent antihyperglycemic modality, yet it suffers from low oral bioavailability.
Nancy M. Lotfy, Mohammed Abdallah Ahmed, Nada M. El Hoffy, Ehab R. Bendas, Nadia M. Morsi   +4 more
doaj   +1 more source

Optimization and Characterization of Aspirin‐ and Ibuprofen‐Loaded Lipid‐Based Nanoparticle Synthesis for Antibacterial Activity and Cytotoxic Effect

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Lipid‐based nanoparticles (LNPs) are favored for drug delivery because of their low toxicity, high biocompatibility, ability to self‐assemble into nanoparticles, and ability to enhance drug bioavailability, thereby improving drug release modulation and pharmacokinetics.
Gulizar Caliskan, Smyrna Ergonul, Zuhal Naz Cansu, Busra Kaplan   +3 more
wiley   +1 more source

Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

Molecules, 2015
The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and ...
Prabagar Balakrishnan, Eun-Kyoung Park, Chung-Kil Song, Hyun-Jeong Ko, Tae-Wook Hahn, Ki-Won Song, Hyun-Jong Cho   +6 more
doaj   +1 more source

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Brian Davis, Roger B. Dodd, Christine Surrette, John Nelson   +8 more
wiley   +1 more source