Results 21 to 30 of about 25,360,752 (379)

Mechanism of ribosome stalling during translation of a poly(A) tail

Nature Structural & Molecular Biology, 2019
Faulty or damaged messenger RNAs are detected by the cell when translating ribosomes stall during elongation and trigger pathways of mRNA decay, nascent protein degradation and ribosome recycling.
V. Chandrasekaran, S. Juszkiewicz, Junhong Choi, J. Puglisi, Alan Brown, S. Shao, V. Ramakrishnan, R. Hegde   +7 more
semanticscholar   +1 more source

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. [PDF]

, 2015
Clinical and neuropathological characteristics associated with G4C2 repeat expansions in chromosome 9 open reading frame 72 (C9ORF72), the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, are highly variable ...
Bieniek, Kevin F, Boeve, Bradley F, Boylan, Kevin B, Castanedes-Casey, Monica, Cleveland, Don W, Crook, Julia E, Daughrity, Lillian M, Desaro, Pamela, Dickson, Dennis W, Edbauer, Dieter, Gendron, Tania F, Graff-Radford, Neill R, Jiang, Jie, Josephs, Keith A, Knopman, David S, Lagier-Tourenne, Clotilde, Lucas, John A, Murray, Melissa E, Overstreet, Karen, Parisi, Joseph E, Pedraza, Otto, Petersen, Ronald C, Petrucelli, Leonard, Rademakers, Rosa, Robertson, Amelia, Rousseau, Linda, Rush, Beth K, Thomas, Colleen S, van Blitterswijk, Marka   +28 more
core   +2 more sources

Evaluation of a poly(lactic-acid) scaffold filled with poly(lactide-co-glycolide)/hydroxyapatite nanofibres for reconstruction of a segmental bone defect in a canine model

Veterinární Medicína, 2019
Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention.
Jang Won Yun, Su Young Heo, Min Ho Lee, Hae Beom Lee   +3 more
doaj   +1 more source

Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation

FEBS Open Bio, 2023
During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added to the newly
Juan B. Rodríguez‐Molina, Matti Turtola   +1 more
doaj   +1 more source

Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails

Nature Communications, 2019
Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined.
Yusheng Liu, Hu Nie, Hongxiang Liu, Falong Lu   +3 more
semanticscholar   +1 more source

Poly(disulfide)s

Chemical Science, 2012
AbstractReview: Scope and limitations of poly(disulfide)s to build modern supramolecular systems; 89 refs.
Bang EK, Lista M, Sforazzini G, Sakai N, Matile S   +4 more
openaire   +5 more sources

Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain

Genome Biology, 2017
BackgroundRecent work has identified and mapped a range of posttranscriptional modifications in mRNA, including methylation of the N6 and N1 positions in adenine, pseudouridylation, and methylation of carbon 5 in cytosine (m5C).
Thomas Amort, D. Rieder, A. Wille, Daria Khokhlova-Cubberley, C. Riml, Lukas Trixl, X. Jia, R. Micura, A. Lusser   +8 more
semanticscholar   +1 more source

Localization Properties of Electronic States in Polaron Model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers [PDF]

, 2004
We numerically investigate localization properties of electronic states in a static model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers with realistic parameters obtained by quantum-chemical calculation.
Barnett, Carpena, Conwell, D. Hennig, Dunlap, E. B. Starikov, H. Yamada, Hennig, Hennig, Hermon, Iguchi, J. F. R. Archilla, LeBard, Lewis, Porath, Roche, Starikov, Tran, Varga, Yamada, Yamada, Yamada, Yoo, Zhang   +23 more
core   +2 more sources

Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

Nature Communications, 2018
Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3′ end of mRNA in nociceptor sensitization.
P. Barragán-Iglesias, Tzu-Fang Lou, Vandita D Bhat, S. Megat, M. Burton, Theodore John Price, Z. Campbell   +6 more
semanticscholar   +1 more source

tailfindr: alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing

bioRxiv, 2019
Polyadenylation at the 3’-end is a major regulator of messenger RNA and its length is known to affect nuclear export, stability and translation, among others.
M. Krause, A. M. Niazi, Kornel Labun, Yamila N. Torres Cleuren, Florian Müller, Eivind Valen   +5 more
semanticscholar   +1 more source