Results 51 to 60 of about 25,360,752 (379)
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
Nature Communications, 2017 FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene ...
S. Mroczek +9 more
semanticscholar +1 more source
Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase
, 2019 The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Conti, E. +6 more
core +1 more source
Poly-Poisson Sigma models and their relational poly-symplectic groupoids
, 2017 The main idea of this note is to describe the integration procedure for poly-Poisson structures, that is, to find a poly-symplectic groupoid integrating a poly-Poisson structure, in terms of topological field theories, namely via the path-space ...
Alba, Nicolás Martínez +1 more
core +1 more source
Translation of poly(A) tails leads to precise mRNA cleavage
RNA: A publication of the RNA Society, 2017 Translation of poly(A) tails leads to mRNA cleavage but the mechanism and global pervasiveness of this “nonstop/no-go” decay process is not understood.
N. Guydosh, R. Green
semanticscholar +1 more source
Poroelastic indentation of mechanically confined hydrogel layers
, 2017 We report on the poroelastic indentation response of hydrogel thin films geometrically confined within contacts with rigid spherical probes of radii in the millimeter range.
Chateauminois, A. +3 more
core +1 more source
RNA: A publication of the RNA Society, 2017 The nuclear poly(A) binding protein (PABPN1) has been suggested, on the basis of biochemical evidence, to play a role in mRNA polyadenylation by strongly increasing the processivity of poly(A) polymerase.
U. Kühn, J. Buschmann, E. Wahle
semanticscholar +1 more source
pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences
Molecular Therapy: Nucleic Acids, 2016 Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in cell engineering and therapeutic applications.
Alexandra E. Grier +10 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Poly(A)-tail profiling reveals an embryonic switch in translational control
Nature, 2014 Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling
Alexander O. Subtelny +4 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source