Results 51 to 60 of about 24,007,230 (395)
Short Poly(A) Tails are a Conserved Feature of Highly Expressed Genes
Nature Structural & Molecular Biology, 2017 Poly(A) tails are important elements in mRNA translation and stability, although recent genome-wide studies have concluded that poly(A) tail length is generally not associated with translational efficiency in nonembryonic cells.
S. Lima +7 more
semanticscholar +1 more source
eLife, 2023 A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) proteins, produced from both
Yoshifumi Sonobe +7 more
doaj +1 more source
The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases
Nature Structural & Molecular Biology, 2019 The 3′ poly(A) tail of messenger RNA is fundamental to regulating eukaryotic gene expression. Shortening of the poly(A) tail, termed deadenylation, reduces transcript stability and inhibits translation.
T. Tang +3 more
semanticscholar +1 more source
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Genome Biology, 2017 Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how
Olivia S. Rissland +9 more
doaj +1 more source
mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome
Nature, 2017 A fundamental principle in biology is that the program for early development is established during oogenesis in the form of the maternal transcriptome. How the maternal transcriptome acquires the appropriate content and dosage of transcripts is not fully
Marcos Morgan +11 more
semanticscholar +1 more source
Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. [PDF]
PLoS ONE, 2014 Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical and calorimetric studies, and ...
Sarita Sarkar +2 more
doaj +1 more source
Translation of poly(A) tails leads to precise mRNA cleavage
RNA: A publication of the RNA Society, 2017 Translation of poly(A) tails leads to mRNA cleavage but the mechanism and global pervasiveness of this “nonstop/no-go” decay process is not understood.
N. Guydosh, R. Green
semanticscholar +1 more source
APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells [PDF]
, 2008 APLF is a novel protein of unknown function that accumulates at sites of chromosomal DNA strand breakage via forkhead-associated (FHA) domain-mediated interactions with XRCC1 and XRCC4.
Caldecott, Keith W +4 more
core +3 more sources
RNA: A publication of the RNA Society, 2017 The nuclear poly(A) binding protein (PABPN1) has been suggested, on the basis of biochemical evidence, to play a role in mRNA polyadenylation by strongly increasing the processivity of poly(A) polymerase.
U. Kühn, J. Buschmann, E. Wahle
semanticscholar +1 more source
Spatial and temporal cellular responses to single-strand breaks in human cells [PDF]
, 2003 DNA single-strand breaks (SSB) are one of the most frequent DNA lesions produced by reactive oxygen species and during DNA metabolism, but the analysis of cellular responses to SSB remains difficult due to the lack of an experimental method to produce ...
Caldecott, Keith W +4 more
core +4 more sources