Results 71 to 80 of about 115,568,697 (304)

Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer

Journal of Translational Medicine, 2019
Background Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential mechanisms underlying this is ...
Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu, Shenglin Ma   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Poly-falling factorial sequences and poly-rising factorial sequences

Open Mathematics, 2021
In this paper, we introduce generalizations of rising factorials and falling factorials, respectively, and study their relations with the well-known Stirling numbers, Lah numbers, and so on.
Kim Hye Kyung
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Check Out the Library, 2022 Spring Issue [PDF]

, 2022
Table of Contents Introduction Our First Cal Poly Humboldt Library Newsletter New Special Collections Website New Spaces & New Faces Our Students are Talking ImPRESSive Growth What’s New in the Makerspace & Digital Media Lab?
Cal Poly Humboldt Library,
core   +1 more source

Temperature patterns in a poly-tubeventilated greenhouse

California Agriculture, 1966
New systems for greenhouse management have been introduced in recent years that necessitate changes in some of the traditional methods of growing greenhouse crops. Evaporative cooling.
P Parvin, R Sciaroni, R Curley
doaj  

Identification of Genes for Improving Cold Sensitivity in Nerve-Damaged Rats Via Lumbar Sympathectomy Using Poly(A)-seq

Journal of Integrative Neuroscience
Background: Lumbar sympathectomy improves blood flow to the lower limbs and is widely used in clinical practice to treat lower limb pain and cold.
Xi Meng, Hanrui Fan, Ping Xu, Lei Yang, Yong Fei, Wenping Zhang   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

An improved method of sncRNA cDNA library construction

四川大学学报. 自然科学版, 2017
With the increasing recognization of sncRNA, especially miRNA and piRNA, it has been proved that small noncoding RNA (sncRNA，
DU Guang-Shi, LUO Fa-Tao, XIAO Yan, CHEN Hong-Jun, WU Chuan-Fang   +4 more
doaj