Results 51 to 60 of about 115,568,697 (304)

A kingdom-wide full-length RNA atlas reveals the evolutionary landscapes of plant poly(A) tails

Genome Biology
Background Poly(A) tails play crucial roles in regulating mRNA degradation and translation, yet their evolutionary dynamics remain largely unexplored. Results Here, we generate a comprehensive full-length RNA atlas of poly(A) tail based on 130 million ...
Yang Chen, Wenqin Lu, Hai He, Lihao Zheng, Xuehua Pan, Ting Sun, Fengjiao Bu, Yuhan Fang, Yufei Sun, Yanping Long, Meina Wang, Shengdan Wu, Lin Liu, Jinbu Jia, Yuannian Jiao, Zhangli Hu, Yu Zhang, Jixian Zhai   +17 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Multifunctional poly(alkyl methacrylate) films for dental care [PDF]

, 2011
Towards the evaluation of non-permanent dental coatings for their capacity to impart dental-care benefits, thin films of a homologous series of comb-like poly(alkyl methacrylate)s (ethyl to octadecyl) have been deposited, from aqueous latex formulations,
Thomas G Nevell, John Tsibouklis, Rees, G., Nielsen, Birthe V., Tsibouklis, John, Nevell, Tom, Eugen Barbu, Nielsen, B., Smith, James, James R Smith, Gareth D Rees, Barbu, Eugen, Smith, James R., Rees, Gareth D., Nevell, Thomas G., GlaxoSmithKline R&D (Gareth D. Rees), Birthe V Nielsen   +16 more
core   +1 more source

Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

Cell Reports, 2020
Summary: Multiple factors influence translation termination efficiency, including nonsense codon identity and immediate context. To determine whether the relative position of a nonsense codon within an open reading frame (ORF) influences termination ...
Chan Wu, Bijoyita Roy, Feng He, Kevin Yan, Allan Jacobson   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Thermotropic and structural effects of poly(malic acid) on fully hydrated multilamellar DPPC–water systems [PDF]

, 2013
The thermotropic and structural effects of low molecular weight poly(malic acid) (PMLA) on fully hydrated multilamellar dipalmitoylphosphatidylcholine (DPPC)-water systems were investigated using differential scanning calorimetry (DSC), small-angle X-ray
Naszályi Nagy, Lívia, Telegdi, Judit, Berényi, Szilvia, Bóta, Attila, Kristyán, Sándor, Mihály, Judith   +5 more
core   +1 more source

Comprehensive study of the radiation shielding feature of polyester polymers impregnated with iron filings

e-Polymers, 2023
Radiation and nuclear technologies have side effects in addition to their important applications, so appropriate shields must be used to protect users and the public from high doses as a result of exposure to this radiation. In this work, the attenuation
Al-Saleh Wafa M., Dahi Mai R. H., Sayyed M. I., Almutairi Haifa M., Saleh I. H., Elsafi Mohamed   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sequence motifs that distinguish ATP(CTP) : tRNA nucleotidyl transferases from eubacterial poly(A) polymerases [PDF]

, 2004
ATP(CTP):tRNA nucleotidyl transferases, tRNA maturing enzymes found in all organisms, and eubacterial poly(A) polymerases, enzymes involved in mRNA degradation, are so similar that until now their biochemical functions could not be distinguished by their
Keller, W., Martin, G.
core