Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study [PDF]
Biomedicines, 2023 Effective options in the quiescent, scantily inflammatory phase of localized scleroderma (morphea) are lacking. A cohort study in patients with histologically confirmed fibroatrophic morphea explored the therapeutic value of the anti-dystrophic A2A ...
Sebastiano Recalcati +2 more
exaly +4 more sources
Impact of Polydeoxyribonucleotides on the Morphology, Viability, and Osteogenic Differentiation of Gingiva-Derived Stem Cell Spheroids [PDF]
Medicina (Lithuania)Background and Objectives: Polydeoxyribonucleotides (PDRN), composed of DNA fragments derived from salmon DNA, is widely recognized for its regenerative properties.
Youngkyung Ko +2 more
exaly +4 more sources
From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules [PDF]
BiomoleculesPolydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation.
Alexis Laurent +2 more
exaly +4 more sources
Salvage of a nasal chondrocutaneous flap after a traumatic avulsion injury using a combination of treatments polydeoxyribonucleotide injection, continuous non-rebreather mask oxygen therapy, and chemical leeching: a case report [PDF]
Archives of Aesthetic Plastic Surgery, 2023 Skin avulsions are severe traumatic injuries, in which sections of skin and subcutaneous tissue are torn off from the body, and the surgical management and salvage of these injuries are quite challenging due to their high morbidity and mortality.
Hook Sun, Min Young Kim, Jin Woo Kim
doaj +3 more sources
Materials and Design, 2023 Conventional wound dressings have several shortcomings because they are unspecific and partially effective for wound healing. To enhance the therapeutic efficiency of wound dressings, we extracted polydeoxyribonucleotides (PDRN) from Patiria pectinifera,
Won Sun Park +2 more
exaly +3 more sources
A novel method to encapsulate polydeoxyribonucleotides extracted from trout into exosomes and applications in skin recovery [PDF]
BMC BiotechnologyPolydeoxyribonucleotide (PDRN), a DNA polymer derived from salmonid tissue, is widely used in regenerative dermatology but its topical application is limited by poor stability and delivery efficiency.
Yunhee Chang +5 more
doaj +2 more sources
Post-blepharoplasty ectropion management: therapeutic benefits of platelet-rich plasma and polydeoxyribonucleotide injections [PDF]
Archives of Aesthetic Plastic SurgeryBackground Ectropion, a common complication after lower blepharoplasty, causes significant patient discomfort and dissatisfaction, yet effective treatments remain lacking.
Hyung Woo Wang +3 more
doaj +3 more sources
New Cellular Treatment Factor (NCTF) and Polydeoxyribonucleotide (VAMP) Injections Enhance Skin Regeneration: Experimental and Histological Evidence. [PDF]
J Cosmet DermatolABSTRACT Background Optimizing cutaneous wound healing remains a priority in dermatology and plastic surgery. Bioactive injectables such as NCTF and VAMP are gaining interest for their potential to enhance angiogenesis and tissue regeneration, yet their combined effects remain underexplored.
Adel N, Kolenda J.
europepmc +2 more sources
Biochemistry and Biophysics Reports, 2020 The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher
Alexander Vedenkin
exaly +3 more sources
Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract [PDF]
Marine DrugsRed microalga Porphyridium cruentum produces a sulfated exopolysaccharide (EPS), which enables its survival in challenging intertidal and spray zones. Extracellular polysaccharide hyaluronic acid (HA) plays important roles in skin hydration, elasticity ...
Fabien Havas +3 more
doaj +2 more sources