From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules [PDF]
BiomoleculesPolydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation.
Alexandre Porcello +2 more
exaly +7 more sources
Impact of Polydeoxyribonucleotides on the Morphology, Viability, and Osteogenic Differentiation of Gingiva-Derived Stem Cell Spheroids [PDF]
Medicina (Lithuania)Background and Objectives: Polydeoxyribonucleotides (PDRN), composed of DNA fragments derived from salmon DNA, is widely recognized for its regenerative properties.
Hye-Jung Song +2 more
exaly +4 more sources
L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells [PDF]
Biochemistry and Biophysics Reports, 2020 The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher
S.V. Stovbun +5 more
exaly +4 more sources
Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study [PDF]
Biomedicines, 2023 Effective options in the quiescent, scantily inflammatory phase of localized scleroderma (morphea) are lacking. A cohort study in patients with histologically confirmed fibroatrophic morphea explored the therapeutic value of the anti-dystrophic A2A ...
Maurizio Romagnuolo +5 more
doaj +2 more sources
Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review [PDF]
Dentistry Journal, 2023 Aim: Polydeoxyribonucleotide (PDRN) is a chain-like polymer derived from DNA. Recent in vitro and animal studies have showcased the beneficial impacts of PDRN on the process of bone mending, whether used on its own or in conjunction with other substances
Mattia Manfredini +5 more
doaj +3 more sources
Materials and Design, 2023 Conventional wound dressings have several shortcomings because they are unspecific and partially effective for wound healing. To enhance the therapeutic efficiency of wound dressings, we extracted polydeoxyribonucleotides (PDRN) from Patiria pectinifera,
Tae-Hee Kim +2 more
exaly +3 more sources
Sequence Specificity in Synthetic Polydeoxyribonucleotides [PDF]
Nature, 1964 KORNBERG has shown that enzymatic synthesis of polydeoxyribonucleic acids from mononucleotides is possible even in the absence of a primer DNA molecule1,2.
D, COHEN, G R, BANKS
exaly +3 more sources
Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract [PDF]
Marine DrugsRed microalga Porphyridium cruentum produces a sulfated exopolysaccharide (EPS), which enables its survival in challenging intertidal and spray zones. Extracellular polysaccharide hyaluronic acid (HA) plays important roles in skin hydration, elasticity ...
Fabien Havas +3 more
doaj +2 more sources
Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts [PDF]
Journal of Functional BiomaterialsPlant-derived polynucleotides (PNs) have emerged as promising regenerative biomolecules; however, their mechanisms remain less defined than those of salmon-derived polydeoxyribonucleotides (S-PDRNs).
Soyoung Hwang +8 more
doaj +2 more sources
Post-blepharoplasty ectropion management: therapeutic benefits of platelet-rich plasma and polydeoxyribonucleotide injections [PDF]
Archives of Aesthetic Plastic SurgeryBackground Ectropion, a common complication after lower blepharoplasty, causes significant patient discomfort and dissatisfaction, yet effective treatments remain lacking.
Hyung Woo Wang +3 more
doaj +3 more sources