Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review [PDF]
Dentistry Journal, 2023 Aim: Polydeoxyribonucleotide (PDRN) is a chain-like polymer derived from DNA. Recent in vitro and animal studies have showcased the beneficial impacts of PDRN on the process of bone mending, whether used on its own or in conjunction with other substances
Mattia Manfredini +5 more
doaj +5 more sources
Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action [PDF]
Applied SciencesPolydeoxyribonucleotides (PDRN), highly purified DNA-derived polymers, were approved by the Italian Medicines Agency (AIFA) in 1994 to treat superficial wounds, skin ulcers, and dystrophic connective tissue disorders.
Seokmuk Park +6 more
doaj +2 more sources
Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering [PDF]
Marine Drugs, 2021 Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon.
Tae-Hee Kim +4 more
doaj +2 more sources
Thienocoumarin derivatives: interaction with nucleic acids and synthetic polydeoxyribonucleotides [PDF]
Journal of Photochemistry and Photobiology B: Biology, 2000 This paper reports the photobiological properties of two new thienocoumarins, 4,6,9-trimethyl-2H-thieno[3,2-g]-1-benzopyran-2-one (compound I) and the 6,9-dimethyl-4-methoxymethyl-2H-thieno[3,2-g]-1-benzopyran-2-one (compound II). Cell growth inhibition studies have revealed significant antiproliferative potency on human tumor cell lines.
GIA, ORNELLA MARIA +5 more
openaire +6 more sources
Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts [PDF]
Journal of Functional BiomaterialsPlant-derived polynucleotides (PNs) have emerged as promising regenerative biomolecules; however, their mechanisms remain less defined than those of salmon-derived polydeoxyribonucleotides (S-PDRNs).
Soyoung Hwang +8 more
doaj +2 more sources
A Novel Classification System of Skinboosters to Support Clinical Decision Making [PDF]
J Cosmet DermatolJournal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
Hong G +4 more
europepmc +2 more sources
Cell Transplantation, 2018 While therapies using mesenchymal stem cells (MSCs) to treat rotator cuff tendon tear (RCTT) have yielded some promising preliminary results, MSCs therapy has not yet completely regenerated full-thickness RCTT (FTRCTT). It has recently been reported that
Sang Chul Lee +2 more
exaly +2 more sources
Prospective Observational Study of Polynucleotide Injections for Periorbital Rhytides. [PDF]
J Cosmet DermatolABSTRACT Introduction Polynucleotides (PN), derived from salmon sperm DNA, are highly purified DNA fragments with reported tissue‐repair and anti‐inflammatory properties mediated through adenosine A2A receptor activation. These agents have been increasingly used in aesthetic dermatology for skin rejuvenation and scar treatment.
Ziade G +6 more
europepmc +2 more sources
Polydeoxyribonucleotide in Female Pattern Hair Loss: Current Evidence and Knowledge Gaps
Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
Nika Bakshi +3 more
openalex +2 more sources
Protective effects of polydeoxyribonucleotides on cartilage degradation in experimental cultures [PDF]
Cell Biochemistry and Function, 2012 The capacity of cartilage self‐regeneration is considered to be limited. Joint injuries often evolve in the development of chronic wounds on the cartilage surface. Such lesions are associated with articular cartilage degeneration and osteoarthritis.
Luisa, Gennero +14 more
openaire +4 more sources