Results 221 to 230 of about 18,599 (272)

Studies on anti-poly(adenosine diphosphate ribose) antibody

Biochemical and Biophysical Research Communications, 1974
Summary Specific antibody against poly(ADP-Rib) was produced in a rabbit by injecting poly(ADP-Rib) mixed with methylated bovine serum albumin. Under standardized conditions, 1 mg of purified anti-poly(ADP-Rib) antibody combined with 400 pmoles (4 μg) of poly(ADP-Rib) and was retained on a millipore filter.
Y, Kanai, M, Miwa, T, Matsushima, T, Sugimura   +3 more
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Poly(adenosine diphosphate ribose) glycohydrolase in Physarum polycephalum

Archives of Biochemistry and Biophysics, 1976
Abstract Poly(adenosine diphosphate ribose) glycohydrolase, which has thus far only been found in mammalian tissues, was found for the first time in the primitive eukaryotic slime mold Physarum polycephalum. The hydrolytic product of poly(adenosine diphosphate ribose) with this enzyme was identified as adenosine diphosphate ribose by paper and thin ...
M, Tanaka, M, Miwa, T, Matsushima, T, Sugimura, S, Shall   +4 more
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Noncovalent interactions of poly(adenosine diphosphate ribose) with histones

Biochemistry, 1992
Covalent linkage of ADP-ribose polymers to proteins is generally considered essential for the posttranslational modification of protein function by poly(ADP-ribosyl)ation. Here we demonstrate an alternative way by which ADP-ribose polymers may modify protein function.
P L, Panzeter, C A, Realini, F R, Althaus   +2 more
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Poly(adenosine diphosphate ribose)

1973
Publisher Summary This chapter discusses that incorporation of radioactivity of (adenine- 14 C) ATP into the acid insoluble material in a nuclear preparation from hen liver is enhanced at least 1000-fold by the presence of NMN. It is confirmed that this stimulation: using a nuclear preparation from rat liver.
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Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

Biochemistry, 1986
Poly(adenosine 5'-diphosphate ribose) [poly(ADP-ribose]) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide, especially in 0.5 M NaCl and at an alkaline pH. The ADP-ribose residues are monomeric and are attached to the middle of polymer chains.
M, Ikejima, D M, Gill
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Relationship between histone H1 poly(adenosine diphosphate-ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate-ribose) antibody

Biochemistry, 1983
The chromatin-associated enzyme poly(ADP-Rib) polymerase catalyzes the posttranslational modification of histones. Antibody to poly(ADP-Rib) has been coupled to Sepharose, and the resultant immunoadsorbent was used to fractionate, specifically, histone H1 subpopulations undergoing this nuclear protein modification.
M, Wong, M, Miwa, T, Sugimura, M, Smulson   +3 more
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Poly(Adenosine Diphosphate Ribose) Polymerase and Deoxyribonucleic Acid Damage

Biochemical Society Transactions, 1977
Several classes of cytotoxic agents are known to affect glycolysis in cells by lowering the cellular concentration of NAD. Early investigations showed that both alkylating agents (Roitt, 1956) and ionizing radiation (Maass et al., 1958) were capable of producing this effect, and subsequent research has largely been confined to these agents. Most of the
M. I. DAVIES, S. SHALL, C. J. SKIDMORE
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IMMUNOHISTOCHEMICAL DEMONSTRATION OF POLY(ADENOSINE DIPHOSPHATE‐RIBOSE) SYNTHESIS IN HUMAN SKIN

The Journal of Dermatology, 1982
ABSTRACTThe distribution of poly(adenosine diphosphate‐ribose) [poly(ADP‐ribose)] synthesis in human skin was investigated by an indirect immunofluorescence technique using a specific antibody against poly(ADP‐ribose). In normal skin, the specific immunofluorescence of poly(ADP‐ribose) was observed in nuclei of not only epidermal cells but also cells ...
K, Ikai, K, Danno, S, Imamura, K, Ueda
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Poly(adenosine diphosphate—ribose) polymerase expression in human traumatic brain injury

Journal of Neurosurgery, 2003
Object. This study was designed to elucidate the pattern of expression of poly(adenosine diphosphate—ribose) polymerase (PARP) in human pericontusional brain tissue and to correlate these findings with commonly used clinical parameters. Methods. The expression of PARP was ascertained using immunohistochemical studies in eight specimens of human ...
Ang, B.T., Yap, E., Lim, J., Tan, W.L., Ng, P.Y., Ng, I., Yeo, T.T.   +6 more
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Role of poly(adenosine diphosphate???ribose) polymerase 1 in septic peritonitis

Current Opinion in Critical Care, 2003
Peritonitis generally results from gastrointestinal perforation, with systemic sepsis developing over hours or days from an initially localized nidus of infection. The consecutive inflammatory response induces the widespread generation of oxidants and free radicals, which are potent inducers of breaks and nicks in double-stranded DNA.
Lucas, Liaudet, Mauro, Oddo
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