Results 1 to 10 of about 159,112 (164)
Nucleoside Diphosphate Sugar Analogues that Target Glycosyltransferases
Asian Journal of Organic Chemistry, 2016 AbstractGlycosyltransferases (GTs) are enzymes that transfer carbohydrates to a range of substrates and they play a fundamental role in the recognition processes associated with several diseases. The design of glycomimetics of nucleoside diphosphate (NDP) sugars—the natural substrates that act as inhibitors or modulators of GTs—is not only necessary ...
Pedro Merino +4 more
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Efficient and Rapid Synthesis of Nucleoside Diphosphate Sugars from Nucleoside Phosphorimidazolides
European Journal of Organic Chemistry, 2013AbstractWe describe a simple, efficient, and protecting‐group‐free, magnesium‐chloride‐promoted synthesis of nucleoside diphosphate sugars from the corresponding nucleoside 5′‐phosphorimidazolides and sugar phosphates in DMF. After optimization, nine different nucleoside sugars were synthesized and isolated in 63–92 % yield, demonstrating the ...
Jacek Jemielity +2 more
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Analytical Biochemistry, 1965
Abstract The enzyme-catalyzed pyrophosphorolysis of nucleoside diphosphate sugars has been followed spectrophotometrically using 3-P-glycerate kinase (EC 2.7.2.3) and glyceraldehyde-3-P dehydrogenase (EC 1.2.1.12) coupled to the oxidation of NADH. The method is rapid, and gives a direct recording of enzyme activity. Some limitations are discussed but
S T Bass, R G Hansen, R G Hansen
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Abstract The enzyme-catalyzed pyrophosphorolysis of nucleoside diphosphate sugars has been followed spectrophotometrically using 3-P-glycerate kinase (EC 2.7.2.3) and glyceraldehyde-3-P dehydrogenase (EC 1.2.1.12) coupled to the oxidation of NADH. The method is rapid, and gives a direct recording of enzyme activity. Some limitations are discussed but
S T Bass, R G Hansen, R G Hansen
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Ion-exchange paper chromatography of nucleoside diphosphate sugars and related nucleotides
Analytical Biochemistry, 1965Abstract A new method especially adapted for the characterization of nucleoside diphosphate sugars in mixtures containing nucleoside mono-, di-, and tri-phosphates is described. It is based on ion-exchange chromatography using papers impregnated with polyethyleneimine (PEI).
Hubert Verachtert +2 more
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Biochimica Et Biophysica Acta: BBA Enzymology and Biological Oxidation, 1966
Abstract The reactivity of eight synthetic analogues of uridine diphosphate glucose with a modified uracyl nucleus in four enzymic systems of uridine diphosphate glucose metabolism has been investigated. For the activity of all of the enzymes studied, the presence of an acylamido grouping −C2(X)N3HC4(X)− (where X = O or S ), appeared necessary.
M A Novikova, V N Shibaev, E I Budowsky
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Abstract The reactivity of eight synthetic analogues of uridine diphosphate glucose with a modified uracyl nucleus in four enzymic systems of uridine diphosphate glucose metabolism has been investigated. For the activity of all of the enzymes studied, the presence of an acylamido grouping −C2(X)N3HC4(X)− (where X = O or S ), appeared necessary.
M A Novikova, V N Shibaev, E I Budowsky
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Journal of Medicinal Chemistry, 1987
The synthesis of alpha-D-glucopyranosyl-, alpha-D-galactopyranosyl-, and alpha-D-mannopyranosylphosphonate is described. Condensation of tris(trimethylsilyl) phosphite with 2,3,4,6-tetrakis-O-(phenylmethyl)-1-O-acetyl-alpha-D-glucopyranose generated 2,3,4,6-tetrakis-O-(phenylmethyl)-alpha-D-glucopyranosylphosphonic acetic anhydride (13).
Ralph J Bernacki, R J Bernacki
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The synthesis of alpha-D-glucopyranosyl-, alpha-D-galactopyranosyl-, and alpha-D-mannopyranosylphosphonate is described. Condensation of tris(trimethylsilyl) phosphite with 2,3,4,6-tetrakis-O-(phenylmethyl)-1-O-acetyl-alpha-D-glucopyranose generated 2,3,4,6-tetrakis-O-(phenylmethyl)-alpha-D-glucopyranosylphosphonic acetic anhydride (13).
Ralph J Bernacki, R J Bernacki
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Chemical and enzymic degradations of nucleoside mono- and diphosphate sugars
Biochimica Et Biophysica Acta - General Subjects, 1979Genevieve Spik, J Montreuil
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[136] Periplasmic enzymes that hydrolyze nucleoside diphosphate sugars
Methods in Enzymology, 1972Luis Glaser
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THE ROLE OF PYRIDINE NUCLEOTIDES IN INTERCONVERSIONS OF NUCLEOSIDE DIPHOSPHATE SUGARS
1972David Sidney Feingold
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A Simple Chemical Synthesis of Sugar Nucleoside Diphosphates in Water
Current Protocols in Nucleic Acid Chemistry, 2013AbstractChemoenzymatic oligosaccharide synthesis is attractive since it eliminates the tedious multistep protection‐deprotection requirements of pure chemical synthesis. Chemoenzymatic synthesis using glycosyltransferases, however, requires not only the correct enzyme to control both regio‐ and stereospecificity, but also the glycosyl donor to provide ...
Hidenori, Tanaka +2 more
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