Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase [PDF]
, 2019 GDP-mannose 3,5-epimerase (GM35E) catalyzes the conversion of GDP-mannose towards GDP-L-galactose and GDP-L-gulose. Although this reaction represents one of the few enzymatic routes towards the production of L-sugars and derivatives, it has not yet been ...
Beerens, Koen +3 more
core +1 more source
Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives [PDF]
, 2016 This work was supported by projects INNPACTO IPT-2011-0752-900000 and BIO2015-64161-R (to J.A.S) of the Spanish Ministry of Economy and Competitiveness ...
Calle, Fernando de la +6 more
core +1 more source
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]
, 2013 O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi +11 more
core +2 more sources
Variety of Nucleotide Sugar Transporters with Respect to the Interaction with Nucleoside Mono- and Diphosphates [PDF]
Journal of Biological Chemistry, 2007 Nucleotide sugar transporters have long been assumed to be antiporters that exclusively use nucleoside monophosphates as antiport substrates. Here we present evidence indicating that two other types of nucleotide sugar transporters exist that differ in their antiport substrate specificity. Biochemical studies using microsomes derived from Saccharomyces
Masatoshi, Muraoka +4 more
openaire +2 more sources
The plant Nudix hydrolase family. [PDF]
, 2008 Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core
Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
core +1 more source
Nucleoside Diphosphate Sugar Hydrolase Gene of Salmonella typhimurium : Chromosomal Location Determined by Intergeneric Crosses [PDF]
Journal of Bacteriology, 1979 The gene specifying a membrane-bound nucleoside diphosphate sugar hydrolase of Salmonella typhimurium was mapped near the metA locus by using intergeneric crosses between this bacterium and Escherichia coli .
N, Minton, J, Gunn, I R, Beacham
openaire +2 more sources
Intrinsic Conformational Energetics Associated with the Glycosyl Torsion in DNA: A Quantum Mechanical Study [PDF]
, 2002 The glycosyl torsion (χ) in nucleic acids has long been recognized to be a major determinant of their conformational properties. χ torsional energetics were systematically mapped in deoxyribonucleosides using high-level quantum mechanical methods, for ...
Foloppe, Nicolas +3 more
core +1 more source
Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater [PDF]
, 2014 The glycosyltransferase SnogD from Streptomyces nogalater transfers a nogalamine moiety to the metabolic intermediate 3′,4′-demethoxynogalose-1-hydroxynogalamycinone during the final steps of biosynthesis of the aromatic polyketide nogalamycin.
Claesson, Magnus +4 more
core +1 more source
A structural and biochemical model of processive chitin synthesis [PDF]
, 2014 Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach +38 more
core +3 more sources