Results 41 to 50 of about 3,075 (166)

Advances and opportunities for computational interrogation of plant proteins

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling, Shaila Musharoff, Laura H. Gunn   +2 more
wiley   +1 more source

Characterization of the Human Blood Group Glycosyltransferases GTA and GTB for the Synthesis of Blood Group Antigens

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
This study presents the highly efficient heterologous production of the human blood group glycosyltransferases GTA/R176A and GTB, along with their comprehensive biochemical and kinetic characterization. Tailored enzyme cascades, involving the bacterial fucosyltransferase FutC and GTA or GTB, generate milligram quantities of various blood group ABH ...
Katja Pöstges, Philip Palm, Kai P. Hussnaetter, Eliška Filipová, Helena Pelantová, Lucie Petrásková, Pavla Bojarová, Vladimír Křen, Lothar Elling   +8 more
wiley   +1 more source

Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man

, 2018
Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes ...
Cho, JW, Kim, DH, Chung, SK, Seo, KC, Jang, IS, Kwon, YG   +5 more
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, Volume 36, Issue 34, 27 April 2026.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

A Two-Stage One-Pot Enzymatic Synthesis of TDP-l-mycarose from Thymidine and Glucose-1-phosphate

, 2016
This report describes a procedure combining six enzymes native to Escherichia coli or Salmonella typhi, such as thymidine kinase (TK), thymidylate kinase (TMK), nucleoside diphosphate kinase (NDK), pyruvate kinase (PK; for ATP regeneration), TDP-glucose ...
Hung-wen Liu (1279131), Yung-nan Liu (1952272), Haruko Takahashi (2003371)   +2 more
core   +1 more source

New Synthesis of Nucleoside Diphosphate Pyranoses via cycloSal-activated Phosphate Donors

, 2007
Nucleosiddiphosphatpyranosen erfüllen in nahezu allen Stoffwechselvorgängen, die den Aufbau einer glycosidischen Bindung zur Folge haben, eine essentielle Funktion.
Wendicke, Silke
core  

Synthesis of 4-Diphosphocytidyl-2-C-methyl-d-erythritol and 2-C-Methyl-d-erythritol-4-phosphate

, 2016
2-C-Methyl-d-erythritol 4-phosphate (MEP, 2) and 4-diphosphocytidyl-2-C-methyl-d-erythritol (CDPME, 3) are metabolites in the MEP pathway for biosynthesis of isoprenoid compounds in bacteria, plant chloroplasts, and algae.
C. Dale Poulter (641717), Andrew T. Koppisch (584413)   +1 more
core   +1 more source

NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities

, 2023
International audienceThe 22 members of the NUDIX (NUcleoside DIphosphate linked to another moiety, X) hydrolase superfamily can hydrolyze a variety of phosphorylated molecules including (d)NTPs and their oxidized forms, nucleotide sugars, capped mRNAs ...
Louise Jenninger, Frederic Morel, van den Wildenberg, Siet,, Layal Ishak, Morel, Frederic,, Jenninger, Louise, van den Wildenberg, Siet, Hofer, Anders,, Hofer, Anders, Louis Debar, Debar, Louis, Jenninger, Louise,, Hofer, A., Siet van den Wildenberg, Garreau-Balandier, Isabelle, Garreau-Balandier, I., Isabelle Garreau-Balandier, Farge, Geraldine, Moretton, A., Ishak, Layal,, Farge, Geraldine,, Ishak, Layal, Vernet, P., Saber Anoosheh, Farge, G., Moretton, Amandine, van den Wildenberg, S., Geraldine Farge, Debar, Louis,, Vernet, Patrick, Moretton, Amandine,, Morel, F., Anoosheh, Saber,, Anoosheh, S., Debar, L., Garreau-Balandier, Isabelle,, Vernet, Patrick,, Anders Hofer, Patrick Vernet, Anoosheh, Saber, Morel, Frederic, Amandine Moretton   +41 more
core   +1 more source