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PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease [PDF]
MedCommThe poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei +9 more
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A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation [PDF]
Nature Communications, 2019 The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.
Xiao-Nan Zhang +9 more
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Poly (ADP-ribose) polymerase inhibitors in cancer therapy [PDF]
Chinese Medical Journal. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) have emerged as critical agents for cancer therapy. By inhibiting the catalytic activity of PARP enzymes and trapping them in the DNA, PARPis disrupt DNA repair, ultimately leading to cell death ...
Ziqi Zhu, Yujun Shi, Jing Ni
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Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors [PDF]
Reviews in Cardiovascular MedicineThe Poly(ADP-ribose) polymerase (PARP) family comprises seventeen members that catalyze poly- or mono- adenosine diphosphate (ADP)-ribosylation, a pivotal post-translational modification regulating a wide array of cellular processes, including ...
Jie Ma +8 more
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Poly(ADP-ribose)polymerase inhibition decreases angiogenesis [PDF]
Biochemical and Biophysical Research Communications, 2006 Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with ...
Batkai, S. +6 more
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Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
PLoS ONE, 2023 CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (
Ekaterina A Maltseva +9 more
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Poly(ADP-Ribose) Polymerase Inhibitors [PDF]
Journal of Thoracic Oncology, 2010 This session not only described several poly(ADP-ribose) polymerase (PARP) inhibitors but also included talks on the science of nuclear excision repair, an oxidized glutathione, and a heat shock protein (HSP) 90 inhibitor. SUMMARY OF PRESENTATIONS Science of Nuclear Excision Repair Dr.
Garon, Edward B., Dubinett, Steven M.
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NAD+ Degrading Enzymes, Evidence for Roles During Infection
Frontiers in Molecular Biosciences, 2021 Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection.
Arnold Tan, Craig L. Doig
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5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]
, 2015 5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola +3 more
core +12 more sources
Journal of Medical Case Reports, 2021 Background Homologous recombination deficiency is a marker of response to poly(ADP-ribose) polymerase inhibitors in different cancer types including ovary, prostate, and pancreatic cancer.
Rosa Montero-Macias +12 more
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