Retracted: Identification of Potential Poly (ADP-Ribose) Polymerase-1 Inhibitors Derived from Rauwolfia serpentina: Possible Implication in Cancer Therapy. [PDF]
Evid Based Complement Alternat Med, 2023 And Alternative Medicine EC.
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Cancer Science, EarlyView.Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu +13 more
wiley +1 more source
Background-Quenched Aggregation-Induced Emission through Electrostatic Interactions for the Detection of Poly(ADP-ribose) Polymerase-1 Activity. [PDF]
Molecules, 2023 Gao F, Zhao R, Huang L, Yi X.
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Cancer Science, EarlyView.AI‐based spatial analysis of tumor‐infiltrating lymphocytes in ovarian cancer revealed the highest infiltration in high‐grade serous carcinoma. Integrating pathology‐based immune phenotypes with HRD status provided additional prognostic insight and highlighted distinct relationships between TILs and genomic structure.
Kohei Hamada +17 more
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Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation. [PDF]
Sci Rep, 2022 Dadheech N +4 more
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New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer
Cancer Science, EarlyView.Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi +2 more
wiley +1 more source
Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure. [PDF]
J Allergy Clin Immunol Glob, 2023 Aguilera J +10 more
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Nonstructural maintenance of chromatin condensin I complex subunit G promotes the progression of glioblastoma by facilitating Poly (ADP-ribose) polymerase 1-mediated E2F1 transactivation. [PDF]
Neuro Oncol, 2023 Hou J +9 more
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The FEBS Journal, EarlyView.Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito +6 more
wiley +1 more source
Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage. [PDF]
Int J Mol Sci, 2022 Mashimo M +8 more
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