Results 131 to 140 of about 63,205 (262)

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Cleavage and inactivation of poly(ADP-ribose) polymerase in peripheral blood mononuclear cells of patients with acute respiratory distress syndrome. [PDF]

Respir Res
Santos SS, Ascenção K, Zuhra K, Martins V, Leite GGF, de Oliveira Cavalcanti Peres Rodrigues L, Hayashi JY, Brunialti MKC, Pecze L, Liaudet L, Vukovic J, Sridharan G, Salomão R, Szabo C.   +13 more
europepmc   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Antitumor activity and structure-activity relationship of poly (ADP-ribose) polymerase (PARP)-based dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
Yang C, Shang Y, Li X, Li J, Li H, Han J.   +5 more
europepmc   +1 more source

Dual‐view scout scans with deep learning for ultra‐low dose attenuation correction in PET

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Accurate attenuation correction (AC) is essential for quantitative positron emission tomography (PET). Conventional CT‐based AC provides reliable attenuation (μ‐) maps but adds radiation, introduces PET/CT misalignment artifacts, and is unavailable on stand‐alone PET systems.
Florence M. Muller, Margaret E. Daube‐Witherspoon, Michael J. Parma, Amy E. Perkins, Peter B. Noël, Christian Vanhove, Stefaan Vandenberghe, Joel S. Karp   +7 more
wiley   +1 more source

Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance. [PDF]

Nucleic Acids Res
Sepšiová R, Procházková K, Červenák F, Majerčík D, Hanáková K, Lattová E, Hajikazemi M, Zdráhal Z, Virágová S, Brzáčová Z, Paeschke K, Nosek J, Tomáška Ľ.   +12 more
europepmc   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Nucleotide excision repair and poly(ADP-ribose) polymerase 1 cooperate in HBV cccDNA synthesis: A potential viral therapeutic target. [PDF]

JHEP Rep
Hung HC, Tsai HW, Li YT, Liu WC, Cheng KH, Yen CJ, Lee YP, Fang YH, Chuang CH, Wu HL, Chang TT, Huang W.   +11 more
europepmc   +1 more source