The FASEB Journal, Volume 40, Issue 16, 31 August 2026.The zinc transporter ZIP1 is induced promptly following treatment with the DNA damage agent bleomycin through the TNFα–NF‐κB pathway. NF‐κB accumulates in the nucleus and upregulates the transcription of SLC39A1, the coding gene for ZIP1. The increased expression of ZIP1 leads to elevated intracellular zinc levels, which, in turn, enhance the DNA ...
Zichong Li +4 more
wiley +1 more source
Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma. [PDF]
Research (Wash D C)Zhou J +11 more
europepmc +1 more source
Synthesis of the Core Tetracycle of the Spirobiflavonoid Daphnodorin C
European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.Core spirotetracycle of daphnodorin C: Oxidative ring contraction of benzofuro[3,2‐b]chromenones affords novel 2,3′‐spirobi[benzofuran]diones, rather than the isomeric spiroketals. The first synthesis of the spirobi[benzofuran]dione core structure of the spirobiflavonoid daphnodorin C is described.
Lukas Heemann +2 more
wiley +1 more source
Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]
PeerJFan J, Song Y.
europepmc +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, Volume 20, Issue 8, Page 1905-1912, August 2026.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience. [PDF]
Cancers (Basel)Akkoc Mustafayev FN +10 more
europepmc +1 more source
Biomedical Chromatography, Volume 40, Issue 8, August 2026.ABSTRACT Olaparib belongs to the PARP inhibitors and is widely used as an anticancer drug. Due to frequent side effects, it is usually co‐administered with an antihypertensive, such as propranolol and/or an antidiuretic, such as furosemide. In this study, a highly sensitive HPLC‐FLD method was developed for the simultaneous determination of the three ...
Georgios Kamaris +2 more
wiley +1 more source
Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells. [PDF]
Transl OncolZhang C +5 more
europepmc +1 more source
Clinical Advances in Breast Cancer: A Comprehensive Overview of Full‐Course Disease Management
Cancer Innovation, Volume 5, Issue 4, August 2026.This review provides a comprehensive overview of clinical advances in breast cancer, highlighting subtype‐specific therapeutic paradigms. It underscores the full‐cycle integration of innovative therapies, as well as the growing role of biomarker‐guided strategies in advancing precision medicine.
Xuenan Peng, Yujing Tan, Fei Ma
wiley +1 more source
Synthetic lethality from the combination of a histone methyltransferase SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma. [PDF]
BMC CancerToyohara Y +17 more
europepmc +1 more source