Results 171 to 180 of about 63,205 (262)

Poly [ADP-Ribose] Polymerase 1 [PDF]

, 2020
openaire   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Targeting PARP1: A Promising Approach for Next-Generation Poly (ADP-ribose) Polymerase Inhibitors. [PDF]

Curr Breast Cancer Rep
Ray A, Opyrchal M.
europepmc   +1 more source

Poly [ADP-Ribose] Polymerase 2 [PDF]

, 2020
openaire   +1 more source

Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development

eFood, Volume 7, Issue 4, August 2026.
Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch, Katarzyna Stępnik, Anna Wawruszak, Estera Okoń, Agata Jarząb, Katarzyna Gaweł‐Bęben, Magdalena Michalak‐Tomczyk, Jacek Jachuła, Magdalena Zdziebło, Paweł Helon, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis. [PDF]

J Mol Med (Berl)
Lin CY, Chao AS, Chao A, Wu RC, Yu AL, Fu CH, Teng YC, Huang RY, Lai CH.   +8 more
europepmc   +1 more source

Poly [ADP-Ribose] Polymerase 3 [PDF]

, 2020
openaire   +1 more source

The Role of Precision Medicine in Neuroblastoma: Targeted Therapies and Personalized Approaches—A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high‐risk patients.
Mosammat Jannatul Mawa, Mohammad Shahangir Biswas, Maksudul Haque, Munna Kumar Podder   +3 more
wiley   +1 more source

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease. [PDF]

Exp Mol Med
Xu W, Wu Y, Mao R, Jia Y, Jiang H, Zhang F, Huang D, He X, Wang C, Huang K.   +9 more
europepmc   +1 more source

Treatment patterns and clinical outcomes in real‐world patients with small‐cell lung cancer in South Korea: A single‐center experience

International Journal of Cancer, Volume 159, Issue 3, Page 719-728, 1 August 2026.
What's New? The emerging role of immunotherapy in small‐cell lung cancer treatment has not been fully elucidated, particularly outside of clinical trials. This single‐center retrospective cohort study examined real‐world treatment patterns and overall survival in South Korea during the 2018–2023 period.
Sehhoon Park, Danbee Kang, Jin Lee, Hyun Ae Jung, Jong‐Mu Sun, Se‐Hoon Lee, Jin Seok Ahn, Hojoon Lee, Hyuna Lim, Xerxes Pundole, Juhee Cho, Myung‐Ju Ahn   +11 more
wiley   +1 more source