Results 221 to 230 of about 43,499 (244)

Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer

Oral Oncology, 2014
Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown single agent activity against tumors with deficiencies in the DNA repair mechanism homologous recombination including, but not limited to those harboring BRCA mutations. We hypothesized that, in the context of homologous recombination deficiency (HRD), PARPi could have an effect in head and ...
Jana Heitmann, Paul Geeleher, Zhixiang Zuo, Ralph R. Weichselbaum, Everett E. Vokes, Sebastian Fetscher, Tanguy Y. Seiwert   +6 more
openaire   +2 more sources

Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors

Drug Discovery Today: Disease Models, 2012
PARP-1 protects cells from endogenous and therapeutically inflicted DNA damage. PARP inhibitors have been under development since 1980 and first entered clinical trial in 2003. They are an exciting new class of drugs that have the potential to increase the efficacy of anticancer DNA damaging agents and to selectively target cells that have defects in ...
openaire   +2 more sources

Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective

European Journal of Cancer, 2023
Thomas J Herzog, Ignace Vergote, Tim French   +2 more
exaly  

A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies

Current Medicinal Chemistry, 2021
Ying Li, Chen-Fu Liu, Guo-Wu Rao
exaly  

Targeting angiogenesis with poly(ADP-ribose) polymerase inhibitors

2007
The process of angiogenesis is mediated by a wide range of factors, including pro-inflammatory cytokines. On the basis of the involvement of inflammation in tumor development and of the dual role of PARP inhibitor as enhancer of chemotherapy or as anti-inflammatory agent we have investigated the ability of PARP inhibitors to affect endothelial ...
MUZI, ALESSIA, Lacal, PM, DORIO, ANNALISA SUSANNA, Ruffini, F, Scarsella, M, Leonetti, C, Xu, W, Zhang, J, TENTORI, LUCIO, GRAZIANI, GRAZIA   +9 more
openaire   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer

The Cochrane Library, 2022
Neil A J Ryan, Jo Morrison
exaly  

Real-world evidence of poly ADP-ribose polymerase inhibitors in the treatment of ovarian cancer: A systematic literature review

Journal of Oncology Pharmacy Practice, 2020
Eric P Borrelli
exaly  

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Ca-A Cancer Journal for Clinicians, 2011
Timothy A Yap, Shahneen Sandhu, Craig P Carden   +2 more
exaly  

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

Biochimie, 1995
Nicola J Curtin, D R Newell, Barbara W Durkacz   +2 more
exaly  

PARP Inhibitors (Poly(ADP-Ribose) Polymerase Inhibitors)

2013
Larry C. Daugherty, Brandon J. Fisher, Christin A. Knowlton, Michelle Kolton Mackay, David E. Wazer, Anthony E. Dragun, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, Lydia T. Komarnicky-Kocher, Fiori Alite, James H. Brashears, Feng-Ming Kong, Jingbo Wang, Christin A. Knowlton, Michelle Kolton Mackay, James H. Brashears, Filip T. Troicki, Feng-Ming Kong, Jingbo Wang, Filip T. Troicki, Jaganmohan Poli, Rene Rubin, Daniel Yeung, Jatinder Palta, Charlie Ma, Lu Wang, Daniel Yeung, Jatinder Palta, Stephan Mose, Filip T. Troicki, Jaganmohan Poli, Filip T. Troicki, Jaganmohan Poli, Felipe A. Calvo, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Daniel J. Indelicato, Robert H. Sagerman, Filip T. Troicki, Jaganmohan Poli, Erik Limbergen, Yan Yu, Laura Doyle, Filip T. Troicki, Jaganmohan Poli, Darek Michalski, M. Saiful Huq, Theodore E. Yaeger, Cheri Yaeger, Brandon J. Fisher, Larry C. Daugherty, Jay E. Reiff, Jo Ann Chalal, Rene Rubin, Lindsay G. Jensen, Loren K. Mell, Ramesh Rengan, Charles R. Thomas, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Christin A. Knowlton, Michelle Kolton Mackay, Charlie Ma, Lu Wang, Edward J. Gracely, Feng-Ming Kong, Jingbo Wang, Christin A. Knowlton, Michelle Kolton Mackay, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Anthony E. Dragun, John P. Christodouleas, Edward J. Gracely, Claudia E. Rübe, Yan Yu, Laura Doyle, Paul J. Schilling, Ramesh Rengan, Charles R. Thomas, Tony S. Quang, Rene Rubin, Theodore E. Yaeger, Stephan Mose, Cheri Yaeger, Ari D. Brooks, T. Wiegel, D. Bottke, A. Ghazal, M. Schrader, Daniel Yeung, Jatinder Palta, Bradley J. Huth, James H. Brashears, James H. Brashears, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Anthony E. Dragun, Claudia E. Rübe, Erik Limbergen, Ramesh Rengan, Charles R. Thomas, Curt Heese, Edward J. Gracely, Filip T. Troicki, Jaganmohan Poli   +117 more
openaire   +1 more source