Results 251 to 260 of about 72,887 (326)

Durable benefit from poly(ADP-ribose) polymerase inhibitors in metastatic prostate cancer in routine practice: biomarker associations and implications for optimal clinical next-generation sequencing testing. [PDF]

ESMO Open
Triner D, Graf RP, Madison RW, Gjoerup O, Tukachinsky H, Ross JS, Quintanilha JCF, Li G, Cheng HH, Pritchard CC, Zurita AJ, Qin Q, Zhang T, Agarwal N, Reichert ZR, Mateo J, Cieslik M, Morgan TM.   +17 more
europepmc   +1 more source

From Coffee Alkaloid to Ovarian Targets: An Integrated Computational Framework for Trigonelline in Ovarian Aging

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This study employs an integrative in silico approach combining network pharmacology, molecular docking, and molecular dynamics simulations to explore the molecular association between trigonelline and ovarian aging, identifying five hub proteins (MMP9, JAK2, PARP1, HDAC1, and CYP3A4) and three major mechanistic axes related to extracellular matrix ...
Woon Shin Yong, Yuankun Han, Yulu Shen, Ningyu Sun, Qinhua Zhang   +4 more
wiley   +1 more source

The promising role of poly(ADP-ribose) polymerase inhibitors in prostate cancer

Asian Journal of Andrology, 2016
Jeanny B Aragon-Ching
doaj   +1 more source

Emerging Therapeutic Synergies: Combining PD-1 Inhibitors With Poly-ADP-Ribose Polymerase (PARP) Inhibitors in the Treatment of Gynecologic Cancers [PDF]

Mohamed Sheeraz Mohamed Azhar, Zhiyu Loh, Francis T Mutamba, Ahmed Algahiny, Nafiu Mukhtar Yunusa, Sharwini Paramasevon, Manar Almusarhed   +6 more
openalex   +1 more source

Anticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytosterols, a form of naturally occurring substance structurally related to cholesterol, have been getting considerable interest due to their possible anticancer properties. Phytosterols induce apoptosis, block the cell cycle, and abrogate the invasion and metastasis of cancer cells, offering a multi‐manifestation treatment of cancer.
Muhammad Shahbaz, Ushna Momal, Asfa Perween, Hammad Naeem, Muzzamal Hussain, Muhammad Imran, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Suliman A. Alsagaby, Waleed Al Abdulmonem, Entessar Al Jbawi, Mohamed A. Abdelgawad, Samy Selim, Soad K. Al Jaouni, Hagar M. Mohamed   +14 more
wiley   +1 more source

Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content [PDF]

, 2009
Chetan P. Hans, Mourad Zerfaoui, Amarjit S. Naura, Dana Troxclair, Jack P. Strong, Khalid Matrougui, A. Hamid Boulares   +6 more
openalex   +1 more source

Outcomes of therapy‐related non‐core binding factor acute myeloid leukemia with venetoclax‐based therapies

HemaSphere, Volume 10, Issue 2, February 2026.
Abstract Prognosis in therapy‐related acute myeloid leukemia (T‐AML) remains poor, but understanding outcomes with venetoclax (VEN)‐based therapy is relevant. We retrospectively analyzed 317 adult patients with newly diagnosed T‐AML focusing on lower intensity therapy (LIT) VEN‐containing regimens.
Jayastu Senapati, Jennifer Croden, Guillermo Garcia‐Manero, Koichi Takahashi, Naval G. Daver, Tapan M. Kadia, Gautam Borthakur, Nicholas James Short, Elias Jabbour, Fadi Haddad, Jennifer Marvin‐Peek, Hussein A. Abbas, Prithviraj Bose, Guilin Tang, Sanam Loghavi, Elizabeth J. Shpall, Jeremy Ramdial, Uday R. Popat, Richard E. Champlin, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. Dinardo   +21 more
wiley   +1 more source

Untapped Potential of Poly(ADP-Ribose) Polymerase Inhibitors: Lessons Learned From the Real-World Clinical Homologous Recombination Repair Mutation Testing. [PDF]

World J Oncol
Lebedeva A, Veselovsky E, Kavun A, Belova E, Grigoreva T, Orlov P, Subbotovskaya A, Shipunov M, Mashkov O, Bilalov F, Shatalov P, Kaprin A, Shegai P, Diuzhev Z, Migiaev O, Vytnova N, Mileyko V, Ivanov M.   +17 more
europepmc   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source