Results 301 to 310 of about 72,887 (326)

Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics

Anti-Cancer Agents in Medicinal Chemistry, 2019
Background:Poly-ADP-ribosylation, that is, adding ADP-ribose moieties to a protein, is a unique type of protein post-translational modification that regulates various cellular processes such as DNA repair, mitosis, transcription, and cell growth. Small-molecule inhibitors of poly-ADP-ribose polymerase 1 (PARP1) have been developed as anticancer agents ...
Nan, Li, Yifan, Wang, Weiye, Deng, Steven H, Lin   +3 more
openaire   +2 more sources

Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench to Bedside

Clinical Oncology, 2014
Poly(ADP-ribose)polymerase (PARP) inhibitors are a novel class of anticancer agents that target the DNA damage response pathways. The enzyme target, PARP, plays a key role in signalling DNA single-strand breaks. Clinical development to date has focused on their potential role in combination with DNA-damaging chemotherapy, where efficacy has been ...
openaire   +3 more sources

Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans

Bioconjugate Chemistry
Poly(ADP-ribose) polymerase inhibitors (PARPi) have been approved for once or twice daily oral use in the treatment of cancers with BRCA defects. However, for some patients, oral administration of PARPi may be impractical or intolerable, and a long-acting injectable formulation is desirable.
Christopher W. Carreras, Shaun D. Fontaine, Ralph R. Reid, Gary W. Ashley, Daniel V. Santi   +4 more
openaire   +2 more sources

Targeting angiogenesis with poly(ADP-ribose) polymerase inhibitors

2007
The process of angiogenesis is mediated by a wide range of factors, including pro-inflammatory cytokines. On the basis of the involvement of inflammation in tumor development and of the dual role of PARP inhibitor as enhancer of chemotherapy or as anti-inflammatory agent we have investigated the ability of PARP inhibitors to affect endothelial ...
MUZI, ALESSIA, Lacal, PM, DORIO, ANNALISA SUSANNA, Ruffini, F, Scarsella, M, Leonetti, C, Xu, W, Zhang, J, TENTORI, LUCIO, GRAZIANI, GRAZIA   +9 more
openaire   +1 more source

Multidisciplinary considerations in the maintenance treatment of poly(ADP‐ribose) polymerase inhibitors for homologous recombination‐proficient, advanced‐stage epithelial ovarian cancer

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Nature Reviews Molecular Cell Biology, 2021
Lori Anne Passmore, Jeff Coller
exaly  

Smart and Multifunctional Materials Based on Electroactive Poly(vinylidene fluoride): Recent Advances and Opportunities in Sensors, Actuators, Energy, Environmental, and Biomedical Applications

Chemical Reviews, 2023
Carlos M Costa, Vanessa F Cardoso, Pedro Martins   +2 more
exaly  

PARP Inhibitors (Poly(ADP-Ribose) Polymerase Inhibitors)

2013
Larry C. Daugherty, Brandon J. Fisher, Christin A. Knowlton, Michelle Kolton Mackay, David E. Wazer, Anthony E. Dragun, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, James H. Brashears, Lydia T. Komarnicky-Kocher, Fiori Alite, James H. Brashears, Feng-Ming Kong, Jingbo Wang, Christin A. Knowlton, Michelle Kolton Mackay, James H. Brashears, Filip T. Troicki, Feng-Ming Kong, Jingbo Wang, Filip T. Troicki, Jaganmohan Poli, Rene Rubin, Daniel Yeung, Jatinder Palta, Charlie Ma, Lu Wang, Daniel Yeung, Jatinder Palta, Stephan Mose, Filip T. Troicki, Jaganmohan Poli, Filip T. Troicki, Jaganmohan Poli, Felipe A. Calvo, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Daniel J. Indelicato, Robert H. Sagerman, Filip T. Troicki, Jaganmohan Poli, Erik Limbergen, Yan Yu, Laura Doyle, Filip T. Troicki, Jaganmohan Poli, Darek Michalski, M. Saiful Huq, Theodore E. Yaeger, Cheri Yaeger, Brandon J. Fisher, Larry C. Daugherty, Jay E. Reiff, Jo Ann Chalal, Rene Rubin, Lindsay G. Jensen, Loren K. Mell, Ramesh Rengan, Charles R. Thomas, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Christin A. Knowlton, Michelle Kolton Mackay, Charlie Ma, Lu Wang, Edward J. Gracely, Feng-Ming Kong, Jingbo Wang, Christin A. Knowlton, Michelle Kolton Mackay, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Anthony E. Dragun, John P. Christodouleas, Edward J. Gracely, Claudia E. Rübe, Yan Yu, Laura Doyle, Paul J. Schilling, Ramesh Rengan, Charles R. Thomas, Tony S. Quang, Rene Rubin, Theodore E. Yaeger, Stephan Mose, Cheri Yaeger, Ari D. Brooks, T. Wiegel, D. Bottke, A. Ghazal, M. Schrader, Daniel Yeung, Jatinder Palta, Bradley J. Huth, James H. Brashears, James H. Brashears, Hedvig Hricak, Oguz Akin, Hebert Alberto Vargas, Anthony E. Dragun, Claudia E. Rübe, Erik Limbergen, Ramesh Rengan, Charles R. Thomas, Curt Heese, Edward J. Gracely, Filip T. Troicki, Jaganmohan Poli   +117 more
openaire   +1 more source

Poly(N-isopropylacrylamide)-based smart hydrogels: Design, properties and applications

Progress in Materials Science, 2021
Ling Wang, Xiao Yang, Yiyu Feng
exaly  

General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis

Nature Catalysis, 2021
Chun-Chi Chen, Ruyi He, Weidong Liu
exaly