Results 151 to 160 of about 86,323 (286)

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

Molecules and Cells, 2018
Hana Hanzlíková, Ilona Kalasová, A. A. Demin, Lewis E. Pennicott, Zuzana Cihlarova, K. Caldecott   +5 more
semanticscholar   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Identification and Characterization of Novel Inhibitors of Human Poly(ADP-Ribose) Polymerase-1. [PDF]

Molecules
Morgan I, Rennert R, Berger R, Hassanin A, Davari MD, Eisenschmidt-Bönn D, Wessjohann LA.   +6 more
europepmc   +1 more source

Poly (ADP-Ribose) Polymerase Inhibitor [PDF]

, 2020
openaire   +1 more source

Genetic Testing Among Black and White Patients With Advanced Prostate Cancer: A Retrospective Analysis of Testing Utilization and Referral Patterns

The Prostate, Volume 86, Issue 4, Page 440-450, March 2026.
ABSTRACT Purpose Genetic testing is recommended but underutilized in advanced prostate cancer. Given known disparities affecting Black patients, we assessed genetic testing completion rates by race. Methods Henry Ford Health's electronic medical record was queried for new prostate cancer diagnoses (1/1/2017–6/30/2022).
Kyle C. McElyea, James P. Purtell, Avery K. Supernois, Courtney M. Rose, Farhan Ibrahim, Mohammed A. Baseer, Sunita Ghosh, Clara Hwang   +7 more
wiley   +1 more source

Poly (ADP-Ribose) Polymerase 1 and 2 in B-Cell Lymphoma: Pathogenic Roles and Therapeutic Implications. [PDF]

Am J Pathol
Molina-Alvarez A, Sanchez-Gonzalez B, Colomo L, Yélamos J.   +3 more
europepmc   +1 more source

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Clinical Cancer Research, 2007
C. Donawho, Yan Luo, Yanping Luo, T. Penning, J. Bauch, J. Bouska, Velitchka Bontcheva-Diaz, B. Cox, T. DeWeese, L. Dillehay, D. Ferguson, N. Ghoreishi-Haack, D. Grimm, R. Guan, E. Han, R. Holley-Shanks, B. Hristov, K. Idler, K. Jarvis, Eric F. Johnson, L. Kleinberg, V. Klinghofer, Loren M. Lasko, X. Liu, K. Marsh, T. Mcgonigal, J. Meulbroek, A. Olson, J. Palma, L. Rodriguez, Yan Shi, Jason A. Stavropoulos, Alan C. Tsurutani, G. Zhu, S. Rosenberg, V. Giranda, D. Frost   +36 more
semanticscholar   +1 more source

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

R2eGIN: Residual Reconstruction Enhanced Graph Isomorphism Network for Accurate Prediction of Poly (ADP-Ribose) Polymerase Inhibitors. [PDF]

Bioinform Biol Insights
Zonyfar C, Njimbouom SN, Mosalla S, Kim JD.   +3 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, Volume 16, Issue 2, Page 432-446, February 2026.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source