Results 161 to 170 of about 86,323 (286)

Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis. [PDF]

J Mol Med (Berl)
Lin CY, Chao AS, Chao A, Wu RC, Yu AL, Fu CH, Teng YC, Huang RY, Lai CH.   +8 more
europepmc   +1 more source

Family-wide analysis of poly(ADP-ribose) polymerase activity

Nature Communications, 2014
Sejal Vyas, I. Matic, Lilen Uchima, Jennifer E. Rood, R. Žaja, R. Hay, I. Ahel, P. Chang   +7 more
semanticscholar   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer. [PDF]

Cell Mol Life Sci
Maluchenko N, Saulina A, Geraskina O, Kotova E, Korovina A, Armeev G, Kirpichnikov M, Feofanov A, Studitsky V.   +8 more
europepmc   +1 more source

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Science, 2016
Yingfei Wang, Ran An, George K E Umanah, Hyejin Park, Kalyani Nambiar, S. Eacker, Bongwoo Kim, L. Bao, Maged M. Harraz, Calvin Chang, Rong Chen, Jennifer E. Wang, T. Kam, J. Jeong, Zhi Xie, Stewart Neifert, J. Qian, S. Andrabi, S. Blackshaw, Heng Zhu, Hongjun Song, G. Ming, V. Dawson, T. Dawson   +23 more
semanticscholar   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

Cancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

Emerging Therapeutic Synergies: Combining PD-1 Inhibitors With Poly-ADP-Ribose Polymerase (PARP) Inhibitors in the Treatment of Gynecologic Cancers. [PDF]

Cureus
Mohamed Azhar MS, Loh Z, Mutamba FT, Algahiny A, Yunusa NM, Paramasevon S, Almusarhed M.   +6 more
europepmc   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. [PDF]

J Atheroscler Thromb
Xie JJ, Yu X, Liao YH, Chen J, Yao R, Chen Y, Liao MY, Ding YJ, Tang TT, Cheng X.   +9 more
europepmc   +1 more source

Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.

Journal of Clinical Oncology, 2015
C. Scott, E. Swisher, S. Kaufmann
semanticscholar   +1 more source