Results 171 to 180 of about 110,473 (315)

Poly(ADP-ribose) Polymerase-1 (PARP-1) Is Required in Murine Cell Lines for Base Excision Repair of Oxidative DNA Damage in the Absence of DNA Polymerase β [PDF]

, 2003
Florence Le Page, Valérie Schreiber, Claudine Dhérin, Gilbert de Murcia, Serge Boiteux   +4 more
openalex   +1 more source

DataSheet_1_Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages.pdf

, 2021
Cassandra L. R. van Doorn (11388245), Sanne A. M. Steenbergen (11758793), Kimberley V. Walburg (8392875), Tom H. M. Ottenhoff (6906818)   +3 more
openalex   +2 more sources

Correction: Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells [PDF]

, 2020
Nicholas Jette, Suraj Radhamani, Greydon Arthur, Ruiqiong Ye, Siddhartha Goutam, Anthony Bolyos, Lars F. Petersen, Pinaki Bose, D. Gwyn Bebb, Susan P. Lees‐Miller   +9 more
openalex   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Profile of olaparib in the treatment of advanced ovarian cancer

International Journal of Women's Health, 2016
Dana M Chase,1,2 Shreya Patel,2,3 Kristin Shields4 1Division of Gynecologic Oncology, The University of Arizona Cancer Center, 2Division of Gynecologic Oncology, 3Creighton University School of Medicine, St Joseph’s Hospital and Medical Center ...
Chase DM, Patel S, Shields K
doaj  

Poly(ADP-ribose) polymerase interacts with novel Drosophila ribosomal proteins, L22 and L23a, with unique histone-like amino-terminal extensions

, 1999
Yumi Koyama, Shoichiro Katagiri, Shuji Hanai, Kazuhiko Uchida, Masanao Miwa   +4 more
openalex   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, Volume 13, Issue 19, 2 April 2026.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source

Correction for Brady et al., “Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity” [PDF]

, 2019
Pamlea N. Brady, Anupam Goel, Margaret A. Johnson   +2 more
openalex   +1 more source

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source