Results 221 to 230 of about 106,568 (297)

A novel glucose beta‐hydroxybutyrate combination improves hypoglycaemia recovery and patient‐reported outcomes in type 1 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3590-3597, May 2026.
Abstract Aims Hypoglycaemia remains a major barrier to optimal diabetes management. Current treatments based on simple sugars have limitations, including rapid glucose fluctuations and persistent neuroglycopenic symptoms. We investigated FLO23011, a novel multi‐substrate energy formulation containing glucose and beta‐hydroxybutyrate, as a superior ...
D. Russell‐Jones, V. Smout, S. Roy, G. Myers, R. Littlewood, F. Shojaee‐Moradie   +5 more
wiley   +1 more source

Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib. [PDF]

J Am Heart Assoc
Koehler RC, Bedirian K, Chen MH, Shi Y, Cao S, Avery BD, Karuppagounder SS, Akhter K, Bibic A, Dawson VL, Dawson TM, Diniz MA, Lamb J, Nagarkatti KA, Chauhan A, Aronowski J, McCullough LD, de Morais AL, Jin X, Ayata C, Kumskova M, Patel RB, Chauhan AK, Leira EC, Kamat PK, Khan MB, Dhandapani KM, Hess DC, Boisserand LSB, Sanganahalli BG, Sansing LH, Lyden PD, SPAN investigators [Link].   +32 more
europepmc   +1 more source

The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments - parallels with other neurodegenerative disorders. [PDF]

Front Pharmacol
Ordaz DA, Gupta K, Bota DA.
europepmc   +1 more source

Melatonin Regulates Arylhydrocarbon Receptor Mediated UVR‐Induced Processes Related to Inflammation, Skin Aging and Carcinogenesis in Human Ex Vivo Skin

Experimental Dermatology, Volume 35, Issue 5, May 2026.
UVR causes formation of AhR and associated damaging molecules in human skin involved in inflammation, skin aging, and carcinogenesis and therefore impairing skin health. Melatonin pre‐incubation of human skin samples protects from UVR by reducing formation of AhR and associated downstream molecules. Thus, melatonin contributes to skin health.
Katharina Pustelnik, Teresa Burner, Wolfram Hoetzenecker, Tobias W. Fischer   +3 more
wiley   +1 more source

Phase 3 clinical trials evaluating poly(ADP-ribose) polymerase inhibition plus immunotherapy for first-line treatment of advanced ovarian cancer. [PDF]

Oncologist
Rimel BJ, Pujade-Lauraine E, Moore K, Pfisterer J, Han S, Cibula D, Reyners A, Redondo A, Papadimitriou C, Eitan R, Pignata S, Glasspool R, Mirza MR, Bodnar L, Duska L, Provencher D, Phaëton R, Bains M, Coskuncay E, Hardy-Bessard AC.   +19 more
europepmc   +1 more source

Intracellular NAD+ Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866‐Induced Senescent Human Umbilical Vein Endothelial Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Vascular endothelial cells maintain vascular homeostasis by releasing mediators with vasoconstrictive and vasorelaxant effects. Prostanoids are bioactive substances synthesised by cyclooxygenase2 (COX2); they preserve vascular function and can increase the risk of cardiovascular disease (CVD) associated with ageing.
Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji   +3 more
wiley   +1 more source

Synthesis of Novel Substituted <i>N</i>‑Heterocycles and Their Use of Selective Poly(ADP-ribose) Polymerase 1 (PARP1) Inhibitors. [PDF]

ACS Med Chem Lett
Zhou X, Liang SH.
europepmc   +1 more source

Clinicopathological Status and Prognostic Factors of Recurrent Epithelial Ovarian Cancer in Japan: Retrospective Survey of JSOG Committee on Gynecologic Oncology

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.
ABSTRACT Aim Despite advancements in maintenance therapies, recurrent epithelial ovarian cancer remains a clinical challenge with varying outcomes. This study aimed to evaluate the clinicopathological status and prognostic factors of patients with recurrent epithelial ovarian cancer.
Yoh Watanabe, Tsukasa Baba, Shu Soeda, Hideki Tokunaga, Wataru Yamagami, Hiroyuki Nomura, Yoichi Kobayashi, Kei Kawana, Kiyoshi Yoshino, Yoshihito Yokoyama, Hirotaka Nishi, Hiroaki Kobayashi, Yukiko Matsuzawa, Shunsuke Oyamada, Satoru Takahashi, Satoru Nagase   +15 more
wiley   +1 more source

Significance of CA125 Monitoring during Maintenance Treatment with Poly(ADP-Ribose) Polymerase Inhibitor in Ovarian Cancer after First-Line Chemotherapy: Multicenter, Observational Study. [PDF]

Oncol Res
Piątek S, Dańska-Bidzińska A, Derlatka P, Szymanowski B, Duchnowska R, Zielińska A, Sawicka N, Gorzeń A, Michalski W, Bidziński M.   +9 more
europepmc   +1 more source

SCL15 Promotes Seed Longevity Acquisition in Arabidopsis thaliana by Enhancing Antioxidant and Repair Mechanisms During Maturation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT To ensure seed longevity and successful germination, orthodox seeds acquire protective and repair mechanisms during the late stage of seed development to counteract the detrimental effects of desiccation and subsequent rehydration, processes often associated with oxidative stress.
Ming‐Jun Gao, Cathy Coutu, Qi Chen, Myrtle Harrington, Rong Zhou, Dwayne Hegedus   +5 more
wiley   +1 more source